Abstract
Overactive bladder (OAB) is a complex of symptoms frequently encountered in the primary
care setting. Impediments to optimal management of OAB include inaccurate perceptions
on the part of patients and primary care providers, e.g., that the symptoms of OAB
represent a natural progression of aging and are beyond the scope of treatment or
that diagnosis and treatment are specialist concerns. Complicating the physician’s
task is the reluctance of many patients to initiate discussion of their OAB symptoms
and the fact that patients often develop disruptive coping strategies rather than
seek medical treatment, possibly because of a belief that OAB is a normal part of
aging rather than an actual medical condition. In most cases, OAB may be managed quite
well by the primary care physician who has an understanding of the pathophysiology
of OAB. This article reviews normal bladder function and then explores pathophysiologic
changes that likely cause the symptoms of OAB.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The American Journal of MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The standardisation of terminology of lower urinary tract function.Neurourol Urodyn. 2002; 21: 167-178
- Prevalence and burden of overactive bladder in the United States.World J Urol. 2003; 20: 327-336
- Focal changes in nerve, muscle, and connective tissue in normal and unstable human bladder.BJU Int. 1999; 84: 953-960
- Management of overactive bladder.N Engl J Med. 2004; 350: 786-799
- Coping strategies and health care–seeking behavior in a US national sample of adults with symptoms suggestive of overactive bladder.Clin Ther. 2001; 23: 1245-1259
- Neurophysiology of stress urinary incontinence.Rev Urol. 2004; 6: S19-S28
- Physiology of incontinence.Clin Geriatr Med. 2004; 20: 409-425
- The overactive bladder and the role of the pelvic floor muscles.BJU Int. 1999; 83: 31-35
- Neurophysiology of lower urinary tract function and dysfunction.Rev Urol. 2003; 5: S3-S10
- New frontiers in the treatment of overactive bladder and incontinence.Rev Urol. 2002; 4: S50-S56
- Current and future pharmacological treatment for overactive bladder.J Urol. 2002; 168: 1897-1913
- M(3) muscarinic receptors mediate contraction of human urinary bladder.Br J Pharmacol. 2002; 136: 641-643
- Antimuscarinics for treatment of overactive bladder.Lancet Neurol. 2004; 3: 46-53
- Cystometric findings in mice lacking muscarinic M2 or M3 receptors.J Urol. 2004; 172: 2460-2464
- Hypertrophy changes the muscarinic receptor subtype mediating bladder contraction from M3 toward M2.Am J Physiol Regul Integr Comp Physiol. 2003; 285: 701-708
- Campbell’s Urology. WB Saunders, Philadelphia2002
- Describing bladder storage function.Urology. 2003; 62: 28-37
- The urothelium in overactive bladder.Urology. 2004; 64: 7-11
- Role of the urothelium in bladder function.Scand J Urol Nephrol Suppl. 2004; 215: 48-53
- Bladder afferents and their role in the overactive bladder.Urology. 2002; 59: 37-42
- Antimuscarinics and the overactive detrusor—which is the main mechanism of action?.Eur Urol. 2003; 43: 1-5
- Gene therapy strategies for urological dysfunction.Trends Mol Med. 2001; 7: 301-316
- Management of overactive bladder and urge urinary incontinence in the elderly patient.Am J Med. 2006; 119: 29S-36S
- Pathophysiology of overactive bladder and urge urinary incontinence.Rev Urol. 2002; 4: S7-S18
- Diagnosis and management of patients with overactive bladder syndrome and abnormal detrusor activity.Nature Clin Pract Urol. 2004; 1: 78-84
- Physiological and morphometric studies into the pathophysiology of detrusor hyperreflexia in neuropathic patients.J Urol. 1995; 153: 1678-1683
- Ultrastructural changes in the aging bladder [in German].Urologe A. 2004; 43: 527-534
- The human urinary bladder in aging.Br J Urol. 1998; 82: 59-64
- Management of detrusor dysfunction in the elderly.Urology. 2004; 63: 17-23
- Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population.J Rheumatol. 1997; 24: 555-559
- Urinary incontinence in women.Am Fam Physician. 2000; 62: 2433-2444
- Evaluation and diagnosis of overactive bladder.Clin Obstet Gynecol. 2002; 45: 193-204
- Management of incontinence for family practice physicians.Am J Med. 2006; 119: 37S-40S
Article info
Identification
Copyright
© 2006 Elsevier Inc. Published by Elsevier Inc. All rights reserved.