The Reply:
We read with interest the letter from Dr. Ziegelstein in response to our publication in the Journal.
1
We must reiterate that we sought to investigate the relation between aspirin dose and aspirin resistance as measured by a point-of-care assay only. The title of our article just reflects what we found and has no suggestions for any actions needed for this observation. It is beyond the scope of the present work to examine the mechanistic explanation for this phenomenon. We concur with the position paper of the International Society on Thrombosis and Haemostasis that we need more studies to link the laboratory findings to adverse clinical events and the benefits of altering antiplatelet therapy based on such a finding.2
With currently available information, modification of existing antiplatelet therapy for reducing the occurrence of aspirin resistance should be discouraged.- Michelson A.D.
- Cattaneo M.
- Eikelboom J.W.
- et al.
Platelet Physiology Subcommittee of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis
Aspirin resistance position paper of the Working Group on Aspirin Resistance.
Aspirin resistance position paper of the Working Group on Aspirin Resistance.
J Thromb Haemost. 2005; 3: 1309-1311
References
- Low-dose aspirin increases aspirin resistance in patients with coronary artery disease.Am J Med. 2005; 118: 723-727
- Aspirin resistance.J Thromb Haemost. 2005; 3: 1309-1311
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- What Is the Answer You Got?The American Journal of MedicineVol. 119Issue 3
- PreviewI appreciated your editorial, “The Answer You Get Depends on the Question You Ask,” in the July 2005 issue of the Journal.1 I was pleased that as editor-in-chief of The American Journal of Medicine, you ask yourself whether the question being asked by an article is important and whether the outcome is predictable. Careful consideration of these issues, as well as of how questions and answers are reported, is critical to a great journal.
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