Abstract
Purpose
Treatment failure for Helicobacter pylori (H. pylori) eradication is encountered in approximately 10-20% of patients, and many studies
have pointed to a link with smoking. To investigate the effects of smoking on eradication
outcome, we performed a meta-analysis.
Methods
A PubMed search was performed to retrieve articles published up to August 2005. Pooled
odds ratio (OR) and differences rate for H. pylori eradication failure in smokers compared with nonsmokers were used as summary statistics.
Meta-regression was used for examining the source of heterogeneity.
Results
Twenty-two published studies (5538 patients), which provided information on eradication
failure according to smoking status, were included in the analysis. The summary OR
for eradication failure among smokers relative to nonsmokers was 1.95 (95% confidence
interval [CI]: 1.55-2.45; P <.01). It corresponds with the differences in eradication rates between smokers and
nonsmokers (8.4% [95% CI: 3.3-13.5%, P <.01]). Meta-regression analysis demonstrated that a high proportion of nonulcer
dyspepsia patients in studies revealed a higher failure rate among smokers, compared
with a low proportion of nonulcer dyspepsia.
Conclusions
Our meta-analysis demonstrated that smoking increases the treatment failure rate for
H. pylori eradication.
Keywords
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Article info
Footnotes
This work was supported in part by a Grant-in-Aid for Cancer Research (17-1) from the Ministry of Health, Labour and Welfare, Tokyo, Japan.
Identification
Copyright
© 2006 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
