The thrombotic microangiopathies, which include thrombotic thrombocytopenic purpura
and hemolytic-uremic syndrome, cause microangiopathic hemolytic anemia, thrombocytopenia,
and ischemic events due to the presence of microvascular occlusive platelet thrombi.
1
Associated mortality exceeded 90% before the introduction of plasma exchange therapy
in the 1970s and still remains as high as 20%.
2
Based on our clinical experience, we hypothesized that high mortality may be partly
due to development of heart failure. However, symptomatic cardiac involvement in patients
with thrombotic microangiopathies is infrequently reported despite pathological studies
demonstrating cardiac microthrombi.
3
,
4
,
5
,
6
,
7
The aims of this study were to determine the incidence of acute heart failure in
adults with thrombotic microangiopathies, its natural history, severity and reversibility
of systolic dysfunction, and associated mortality rate.To read this article in full you will need to make a payment
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© 2005 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
