Abstract
Purpose
To assess if the treatment and control of hypertension aggregates in families.
Methods
The Genetic Epidemiology Network of Arteriopathy (GENOA) study enrolled sibships between
1997 and 1999, including 1329 hypertensive non-Hispanic blacks (1057 sibling pairs)
from Jackson, Mississippi, 1133 hypertensive non-Hispanic whites (859 sibling pairs)
from Rochester, Minnesota, and 752 hypertensive Hispanic whites (627 sibling pairs)
from Starr County, Texas. Hypertension awareness and drug treatment were ascertained
at examination; control was defined by blood pressure levels <140/90 mm Hg. As a measure
of familial aggregation, odds ratios were calculated to assess concordance between
sibling pairs in the treatment and control of hypertension.
Results
Overall, 90.5% of subjects were aware of their hypertension; 90.6% of those who were
aware were treated with antihypertensive drugs and 56.0% of those treated had their
hypertension controlled. There was statistically significant sib-sib concordance in
the treatment of hypertension (odds ratio [OR] = 1.61; 95% confidence interval [CI]:
1.25 to 2.47; P = 0.003) and in the control of drug-treated hypertension (OR = 1.51; 95% CI: 1.25 to
1.81; P <0.0001).
Conclusion
These findings suggest that the treatment and control of hypertension aggregates in
families.
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Article info
Publication history
Accepted:
November 21,
2003
Received in revised form:
November 21,
2003
Received:
April 3,
2003
Footnotes
☆This work was supported by United States Public Health Service grants HL54464, HL54457, HL54504, HL54463, HL54481, HL54526, and HL68737, and funds from the Mayo Foundation.
Identification
Copyright
© 2004 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
