Abstract
Background
Many studies have reported the presence of simian virus 40 (SV40) deoxyribonucleic
acid (DNA) or protein in human brain tumors and bone cancers, malignant mesothelioma,
and non-Hodgkin’s lymphoma. However, the small samples and lack of control groups
in some reports have made it difficult to assess their reliability.
Methods
Studies were included in this analysis if they met the following criteria: original
studies of patients with primary brain tumors and bone cancers, malignant mesothelioma,
or non-Hodgkin’s lymphoma; the investigation of SV40 was performed on primary cancer
specimens; the analysis included a control group; and the same technique was used
for cases and controls. Included reports were published from 1975 to 2002.
Results
Thirteen studies fulfilled the criteria for the investigation of primary brain cancers
(661 tumors and 482 control samples). Specimens from patients with brain tumors were
almost four times more likely to have evidence of SV40 infection than were those from
controls (odds ratio [OR] = 3.9; 95% confidence interval [CI]: 2.6 to 5.8). The association
was even stronger for mesothelioma (OR = 17; 95% CI: 10 to 28; based on 15 studies
with 528 mesothelioma samples and 468 control samples) and for bone cancer (OR = 25;
95% CI: 6.8 to 88; based on four studies with 303 cancers and 121 control samples).
SV40 DNA was also more frequent in samples from patients with non-Hodgkin’s lymphoma
(OR = 5.4; 95% CI: 3.1 to 9.3; based on three studies with 301 cases and 578 control
samples) than from controls.
Conclusion
These results establish that SV40 is associated significantly with brain tumors, bone
cancers, malignant mesothelioma, and non-Hodgkin’s lymphoma. Studies are needed to
assess current prevalence of SV40 infections.
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References
- Cell and molecular biology of simian virus 40.J Natl Cancer Inst. 1999; 91: 119-134
Second International Conference on Live Poliovirus Vaccines. Papers and Discussions. Washington, DC: The Pan American Health Organization and The World Health Organization; 1960. Scientific Publication No. 50
- Conventional epidemiology and the link between SV40 and human cancers.Lancet Oncol. 2003; 4: 188-191
- SV40 Contamination of Polio Vaccine and Cancer. Immunization Safety Review Committee, Board of Health Promotion and Disease Prevention, Institute of Medicine of the National Academies.in: The National Academies Press, Washington DC2002
- Serologic evidence for a simian-virus-40-like infection of man.J Natl Cancer Inst. 1972; 48: 557-561
- Serological evidence of SV40 infections in HIV-infected and HIV-negative adults.J Med Virol. 1998; 54: 276-284
- Evidence of SV40 infections in hospitalized children.Hum Pathol. 1999; 30: 1496-1502
- Molecular identification of SV40 infections in human subjects and possible association with kidney disease.J Am Soc Nephrol. 2002; 13: 2320-2330
- Sewage yields clue to SV40 transmission.JAMA. 2002; 288: 1337-1338
- Natural simian virus 40 strains are present in human choroid plexus and ependymoma tumors.Virology. 1995; 212: 710-717
- Meta-analysis in clinical research.Ann Intern Med. 1987; 107: 224-233
- Application of polymerase chain reaction to the diagnosis of infectious diseases.Clin Infect Dis. 1999; 29: 475-486
- Bias in the one-step method for pooling study results.Stat Med. 1990; 9: 247-252
- Can meta-analysis be trusted?.Lancet. 1991; 338: 1127-1130
- Operating characteristics of a rank correlation test for publication bias.Biometrics. 1994; 50: 1088-1101
- Bias in meta-analysis detected by a simple, graphical test.BMJ. 1997; 315: 629-634
- Simian virus 40-related antigens in three human meningiomas with defined chromosome loss.Proc Natl Acad Sci USA. 1975; 72: 609-613
- Simian virus 40-related DNA sequences in a human brain tumor.Neurology. 1979; 29: 1590-1594
- Episomal simian virus 40 genomes in human brain tumors.Proc Natl Acad Sci USA. 1981; 78: 6446-6450
- Papovavirus-related RNA sequences in human neurogenic tumours.Acta Neuropathol (Berl). 1982; 56: 118-122
- Association of polyomaviruses JC, SV40, and BK with human brain tumors.Virology. 1987; 160: 268-270
- DNA sequences similar to those of simian virus 40 in ependymomas and choroid plexus tumors of childhood.N Engl J Med. 1992; 326: 988-993
- SV40 early region and large T antigen in human brain tumors, peripheral blood cells, and sperm fluids from healthy individuals.Cancer Res. 1996; 56: 4820-4825
- Detection of SV40 T antigen genome in human gliomas.Brain Tumor Pathol. 1997; 14: 125-129
- Expression of the simian virus 40 large tumor antigen (Tag) and formation of Tag-p53 and Tag-pRb complexes in human brain tumors.Cancer. 1999; 86: 2124-2132
- Low frequency of SV40, JC and BK polyomavirus sequences in human medulloblastomas, meningiomas and ependymomas.Brain Pathol. 2000; 10: 85-92
- Tissue-specific expression of SV40 in tumors associated with the Li-Fraumeni syndrome.Oncogene. 2001; 20: 4441-4449
- Different simian virus 40 genomic regions and sequences homologous with SV40 large T antigen in DNA of human brain and bone tumors and of leukocytes from blood donors.Cancer. 2002; 94: 1037-1048
- Absence of simian virus 40 in human brain tumors from Northern India.Int J Cancer. 2002; 101: 348-352
- Simian virus 40-like DNA sequences in human pleural mesothelioma.Oncogene. 1994; 9: 1781-1790
- Molecular biology studies on mesothelioma tumor samples.J Environ Pathol Toxicol Oncol. 1995; 14: 29-34
- Simian virus 40 large T antigen (SV40LTAg) primer specific DNA amplification in human pleural mesothelioma tissue.Thorax. 1996; 51: 1074-1076
- SV40 expression in human neoplastic and non-neoplastic tissues.Dev Biol Stand. 1998; 94: 361-367
- Detection of SV40 sequences in human mesothelioma.Dev Biol Stand. 1998; 94: 127-136
- Presence of simian virus 40 sequences in malignant pleural, peritoneal and noninvasive mesotheliomas.Int J Cancer. 2000; 85: 743-745
- Simian virus 40 is present in most United States human mesotheliomas, but it is rarely present in non-Hodgkin’s lymphoma.Chest. 1999; 116: 470S-473S
- Detection of SV40 like viral DNA and viral antigens in malignant pleural mesothelioma.Eur Respir J. 1999; 14: 1381-1386
- SV40 large T-antigen and human pleural mesothelioma.Virchows Arch. 1999; 435: 1-7
- SV40, JC and BK expression in tissue, urine and blood samples from patients with malignant and nonmalignant pleural disease.Anticancer Res. 2000; 20: 885-889
- Simian virus-40 sequences are a negative prognostic cofactor in patients with malignant pleural mesothelioma.Genes Chromosomes Cancer. 2000; 29: 173-179
- Simian virus 40 is not a cofactor in the pathogenesis of environmentally induced malignant pleural mesothelioma in Turkey.Anticancer Res. 2000; 20: 891-894
- A multicenter evaluation of assays for detection of SV40 DNA and results in masked mesothelioma specimens.Cancer Epidemiol Biomarkers Preven. 2001; 10: 523-532
- Aberrant methylation and simian virus 40 Tag sequences in malignant mesothelioma.Cancer Res. 2001; 61: 5727-5730
- SV40 infection induces telomerase activity in human mesothelial cells.Oncogene. 2002; 21: 1434-1442
- SV40-like sequences in human bone tumors.Oncogene. 1996; 13: 527-535
- Integration of SV40 in human osteosarcoma DNA.Oncogene. 1998; 17: 2457-2462
- High incidence of SV40-like sequences detection in tumour and peripheral blood cells of Japanese osteosarcoma patients.Br J Cancer. 2000; 82: 1677-1681
- Simian virus 40 is present in human lymphomas and normal blood.Cancer Lett. 2001; 162: 57-64
- Presence of simian virus 40 DNA sequences in human lymphomas.Lancet. 2002; 359: 851-852
- Association between simian virus 40 and non-Hodgkin’s lymphoma.Lancet. 2002; 359: 817-823
- SV40 DNA in human osteosarcomas shows sequence variation among T-antigen genes.Int J Cancer. 1997; 72: 791-800
- Identification in human brain tumors of DNA sequences specific for SV40 large T antigen.Brain Pathol. 1999; 9: 33-42
- Screening of human brain tumors for SV40-related T antigen.Int J Cancer. 1978; 21: 12-17
- More about cell and molecular biology of simian virus 40.J Natl Cancer Inst. 2000; 92: 495-497
- Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas.Proc Natl Acad Sci USA. 1999; 96: 11519-11524
- Detection of simian virus 40 DNA sequence in human primary glioblastomas multiforme.J Neurosurg. 2001; 95: 96-101
- The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas.Nat Med. 1997; 3: 913-916
- Simian virus-40 large-T antigen binds p53 in human mesotheliomas.Nat Med. 1997; 3: 908-912
- Simian virus 40 and pleural mesothelioma in humans.Cancer Epidemiol Biomarkers Prev. 1996; 5: 473-475
- A multi-institutional study confirms the presence and expression of simian virus 40 in human malignant mesotheliomas.Cancer Res. 1998; 58: 4505-4509
- Simian virus 40-like DNA sequences and large-T antigen-retinoblastoma family protein pRb2/p130 interaction in human mesothelioma.Dev Biol Stand. 1998; 94: 47-53
- Further validation of SV40-like DNA in human pleural mesotheliomas.Dev Biol Stand. 1998; 94: 143-145
- Simian virus 40 footprints in human lymphoproliferative disorders for HIV– and HIV+ patients.Int J Cancer. 1998; 78: 669-674
- Simian virus 40 (SV40)-like DNA sequences not detectable in Finnish mesothelioma patients not exposed to SV40-contaminated polio vaccines.Mol Carcinog. 1999; 26: 93-99
- Mutations of p53 gene and SV40 sequences in asbestos associated and non-asbestos-associated mesotheliomas.J Clin Pathol. 1999; 52: 291-293
- Simian virus 40 and human pleural mesothelioma.Thorax. 1999; 54: 60-61
- SV40 can be reproducibly detected in paraffin-embedded mesothelioma samples.Anticancer Res. 2000; 20: 895-898
- Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences.Neuro-oncol. 2002; 4: 165-170
- Presence of simian virus 40 (SV40) is not frequent in Swedish malignant mesotheliomas.Anticancer Res. 2002; 22: 1357-1360
- Reappraisal of the strong association between simian virus 40 and human malignant mesothelioma of the pleura (Belgium).Cancer Causes Control. 2002; 13: 121-129
- Detection of SV40 DNA sequences in malignant mesothelioma specimens from the United States, but not from Turkey.J Cell Biochem. 2002; 84: 455-459
- SV40 sequences in human osteosarcoma of German origin.Anticancer Res. 2000; 20: 4539-4545
- Simian virus (SV) 40 like sequences in cell lines and tumour biopsies from Australian malignant mesotheliomas.Aust NZ J Med. 2000; 30: 450-456
- SV40-like DNA sequences in pleural mesothelioma, bronchopulmonary carcinoma, and non-malignant pulmonary diseases.J Pathol. 1998; 184: 252-257
- Absence of SV40 large T-antigen expression in human mesothelioma cell lines.Am J Respir Cell Mol Biol. 2000; 23: 788-793
- SV40 replication in human mesothelial cells induces HGF/Met receptor activation.Proc Natl Acad Sci USA. 2001; 98: 12032-12037
- Absence of SV40 large T antigen (Tag) in malignant mesothelioma effusions.Diagn Cytopathol. 2001; 25: 203-207
- SV40 Tag-specific cytotoxic T lymphocytes generated from the peripheral blood of malignant pleural mesothelioma patients.Cancer Immunol Immunother. 2002; 50: 682-690
- Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells.Oncogene. 2002; 21: 4340-4344
- The presence of simian virus 40 sequences in mesothelioma and mesothelial cells associated with high levels of vascular endothelial growth factor.Am J Respir Cell Mol Biol. 2002; 26: 189-193
- Enhanced expression of vascular endothelial growth factor plays a critical role in the tumor progression potential induced by simian virus 40 large T antigen.Oncogene. 2002; 21: 2896-2900
- Molecular characterization of SV40 DNA in multiple samples from a human mesothelioma.Anticancer Res. 2000; 20: 879-884
- Pathology and Genetics of Tumors of the Nervous System.in: World Health Organization Classification of Tumours. 1st ed. IARC Press, Lyon, France2000
- Pathology and Genetics of Tumours of Hematopoietic and Lymphoid Tissues.in: World Health Organization of Tumours. IARC Press, Lyon, France2001
- Diagnostic Histopathology of Tumors. 2nd ed. Churchill Livingstone, New York2000
- SEER Cancer Statistics Review, 1973–1998. National Cancer Institute, Bethesda, MD2001 (Available at: http://seer.cancer.gov/Publications/CSR1973_1998/)
- Malignant bone tumors.in: Ries L.A.G Smith M.A Gurney J.G Cancer Incidence and Survival among Children and Adolescents; United States SEER Program 1975–1995. National Cancer Institute, Bethesda, Maryland1999: 99-110 (NIH publication 99-4649)
- Unique strains of SV40 in commercial poliovaccines from 1955 not readily identifiable with current testing for SV40 infection.Cancer Res. 1999; 59: 6103-6108
- Class I major histocompatibility proteins as cell surface receptors for simian virus 40.J Virol. 1989; 63: 4474-4477
- Class I major histocompatibility proteins are essential component of the simian virus 40 receptor.J Virol. 1992; 66: 2037-2045
- Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease.Carcinogenesis. 2000; 21: 405-426
- T antigens of simian virus 40.Microbiol Mol Biol Rev. 2002; 66: 179-202
- Transforming functions of simian virus 40.Oncogene. 2001; 20: 7899-7907
Article Info
Publication History
Accepted:
December 20,
2002
Received in revised form:
December 11,
2002
Received:
June 13,
2002
Footnotes
☆This study was supported in part by the Baylor Center for AIDS Research Core Support Grant AI36211 from the National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. Dr. Vilchez is the recipient of the 2001 Junior Faculty Development Award from GlaxoSmithKline, Philadelphia, Pennsylvania, and the 2002 Translational Research Award from the Leukemia & Lymphoma Society, White Plains, New York. The funding sources had no role in study design; the collection, analysis, or interpretation of data; and the preparation, review, or approval of the manuscript.
Identification
Copyright
© 2003 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
