Advertisement

Rapid suppression of alcohol withdrawal syndrome by baclofen

      Alcohol withdrawal syndrome is a distressing and at times life-threatening condition in alcohol-dependent patients (
      • Lerner W.D.
      • Fallon H.J.
      The alcohol withdrawal syndrome.
      ). Usually, symptoms develop within 6–24 hours after the last drink (
      • Hall W.
      • Zador D.Z.
      The alcohol withdrawal syndrome.
      ). Early symptoms include raised blood pressure and pulse rate, tremor, hyperreflexia, and anxiety with increased irritability. Clinical management is aimed at symptom relief, prevention of seizures and delirium, and a smooth transition to a treatment program to maintain long-term abstinence from alcohol (
      • O’Connor P.G.
      • Schottenfeld R.S.
      Patients with alcohol problems.
      ). Benzodiazepines are presently the drug of choice (
      • Mayo-Smith M.F.
      Pharmacological management of alcohol withdrawal a meta-analysis and evidence-based practice guideline. American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal.
      ).
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Lerner W.D.
        • Fallon H.J.
        The alcohol withdrawal syndrome.
        N Engl J Med. 1985; 313: 951-952
        • Hall W.
        • Zador D.Z.
        The alcohol withdrawal syndrome.
        Lancet. 1997; 349: 1897-1900
        • O’Connor P.G.
        • Schottenfeld R.S.
        Patients with alcohol problems.
        N Engl J Med. 1998; 338: 592-602
        • Mayo-Smith M.F.
        Pharmacological management of alcohol withdrawal.
        JAMA. 1997; 278: 144-151
        • Davidoff R.A.
        Antispasticity drugs: mechanisms of action.
        Ann Neurol. 1985; 17: 107-116
        • Colombo G.
        • Agabio R.
        • Carai M.A.
        • et al.
        Ability of baclofen in reducing alcohol intake and withdrawal severity.
        Alcohol Clin Exp Res. 2000; 1: 58-66
        • Addolorato G.
        • Caputo F.
        • Capristo E.
        • et al.
        Ability of baclofen in reducing alcohol craving and intake.
        Alcohol Clin Exp Res. 2000; 1: 67-71
        • American Psychiatric Association
        Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition. American Psychiatric Association, Washington, DC1994
        • Sullivan J.T.
        • Sykora K.
        • Schneiderman J.
        • et al.
        Assessment of alcohol withdrawal.
        Br J Addict. 1989; 84: 1353-1357
        • Holbrook A.H.
        • Crowther R.
        • Cheng C.
        Diagnosis and management of acute alcohol withdrawal.
        Can Med Assoc J. 1999; 160: 675-680
        • Bashai N.N.
        Providing cost efficient detoxification services to alcohol-dependent patients.
        Public Health Rep. 1990; 105: 475-481
        • Krupitsky E.M.
        • Burakov A.M.
        • Ivanov V.B.
        • et al.
        Baclofen administration for the treatment of affective disorders in alcohol-dependent patients.
        Drug Alcohol Depend. 1993; 33: 157-163
        • Akhondzadeh S.
        • Ahmadi-Abhari S.A.
        • Assadi S.M.
        • et al.
        Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal.
        J Clin Pharm Ther. 2000; 25: 347-353