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Central diabetes insipidus due to lymphocytic infundibuloneurohypophysitis

      Lymphocytic infundibuloneurohypophysitis was recently reported by Kojima et al (
      • Kojima H.
      • Nojima T.
      • Nagashima K.
      • et al.
      Diabetes insipidus caused by lymphocytic infundibuloneurohypophysitis.
      ) and Imura et al (
      • Imura H.
      • Nakao K.
      • Shimatsu A.
      • et al.
      Lymphocytic infundibuloneurohypophysitis as a cause of central diabetes insipidus.
      ) as a cause of idiopathic central diabetes insipidus. We report 2 patients with central diabetes insipidus who had abnormal findings on magnetic resonance imaging (MRI) that were compatible with this syndrome. One of the patients had bilateral enlarged salivary glands that showed an infiltration of activated T lymphocytes, as has been reported in the pituitary stalk among patients with lymphocytic infundibuloneurohypophysitis. Both patients had antibodies for the p24 antigen of the human T lymphocytic leukemia virus-1 (HTLV-1), as well as having the human leukocyte antigen (HLA)-A24 haplotype.
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