Abstract
BACKGROUND: The prognostic significance of proteinuria in older people is not well
defined. We examined the associations between proteinuria and incident coronary heart
disease, cardiovascular mortality, and all-cause mortality in older people.
SUBJECTS AND METHODS: Casual dipstick proteinuria was determined in 1,045 men (mean
[± SD] age 68 ± 7 years) and 1,541 women (mean age 69 ± 7 years) attending the 15th
biennial examination of the Framingham Heart Study. Participants were divided by grade
of proteinuria: none (85.3%), trace (10.2%), and greater-than-trace (4.5%). Cox proportional
hazards analyses were used to determine the relations of baseline proteinuria to the
specified outcomes, adjusting for other risk factors, including serum creatinine level.
RESULTS: During 17 years of follow-up, there were 455 coronary heart disease events,
412 cardiovascular disease deaths, and 1,214 deaths. In men, baseline proteinuria
was associated with all-cause mortality (hazards ratio [HR] = 1.3, 95% confidence
interval [CI] 1.0 to 1.7 for trace proteinuria; HR = 1.3, 95% CI 1.0 to 1.8 for greater-than-trace
proteinuria; P for trend = 0.02). In women, trace proteinuria was associated with cardiovascular
disease death (HR = 1.6, 95% CI 1.1 to 2.4), and all-cause mortality (HR = 1.4, 95%
CI 1.1 to 1.7).
CONCLUSION: Proteinuria is a significant, although relatively weak, risk factor for
all-cause mortality in men and women, and for cardiovascular disease mortality in
women.
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Article info
Publication history
Published online: August 16, 2004
Accepted:
March 31,
2000
Received in revised form:
March 31,
2000
Received:
August 20,
1999
Footnotes
☆Supported by NIH/NHLBI Contract N01-HC-38038. Dr. Culleton is a recipient of the 1997–1999 Kidney Foundation of Canada Fellowship.
Identification
Copyright
© 2000 Excerpta Medica Inc. Published by Elsevier Inc. All rights reserved.
