Abstract
Background
Energy drink consumption has been anecdotally linked with sudden cardiac death and,
more recently, myocardial infarction. As myocardial infarction is strongly associated
with both platelet and endothelial dysfunction, we tested the hypothesis that energy
drink consumption alters platelet and endothelial function.
Methods
Fifty healthy volunteers (34 male, aged 22±2 years) participated in the study. Platelet aggregation and endothelial function
were tested before, and 1 hour after, the consumption of 250 mL (1 can) of a sugar-free
energy drink. Platelet function was assessed by adenosine diphosphate-induced (1 μmol/L)
optical aggregometry in platelet-rich plasma. Endothelial function was assessed via
changes in peripheral arterial tonometry and expressed as the reactive hyperemia index
(RHI).
Results
Compared with baseline values, there was a significant increase in platelet aggregation
following energy drink consumption, while no change was observed with control (13.7±3.7% vs 0.3±0.8% aggregation, respectively, P <.01). Similarly, RHI decreased following energy drink consumption (−0.33±0.13 vs 0.07±0.12 RHI [control], P <.05). Mean arterial pressure significantly increased following energy drink consumption,
compared with control (P <.05). Heart rate was unaffected by energy drink consumption.
Conclusion
Energy drink consumption acutely increases platelet aggregation and decreases endothelial
function in healthy young adults.
Keywords
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References
- A survey of energy drink consumption patterns among college students.Nutr J. 2007; 6: 35
- The health effects of stimulant drinks.Br Nutr Found Nutr Bull. 2003; 28: 147-155
- Cardiac arrest in a young man following excess consumption of caffeinated “energy drinks”.Med J Aust. 2009; 190: 41-43
- Effect of “energy drink” consumption on hemodynamic and electrocardiographic parameters in healthy young adults.Ann Pharmacother. 2009; 43: 596-602
- Influence of energy drinks and alcohol on post-exercise heart rate recovery and heart rate variability.Clin Physiol Funct Imaging. 2009; 29: 74-80
- Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease.Circulation. 2000; 101: 1899-1906
- Platelet nitric oxide responsiveness: a novel prognostic marker in acute coronary syndromes.Arterioscler Thromb Vasc Biol. 2005; 25: 2661-2666
- The deleterious effects of hyperglycemia on platelet function in diabetic patients with acute coronary syndromes mediation by superoxide production, resolution with intensive insulin administration.J Am Coll Cardiol. 2007; 49: 304-310
- Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide.Eur Heart J. 2002; 23: 1946-1954
- Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude.Am Heart J. 2003; 146: 168-174
- Effect of coffee drinking on platelets: inhibition of aggregation and phenols incorporation.Br J Nutr. 2008; 100: 1276-1282
- Effects of acute administration of caffeine on vascular function.Am J Cardiol. 2006; 98: 1538-1541
- The relationship of coffee consumption with mortality.Ann Intern Med. 2008; 148: 904-914
- Taurine: biological update.Annu Rev Biochem. 1986; 55: 427-453
- Taurine and vitamin C modify monocyte and endothelial dysfunction in young smokers.Circulation. 2003; 107: 410-415
Article info
Footnotes
Funding: Dr. Sanders is supported by the National Heart Foundation of Australia.
Conflict of Interest: No author has a conflict of interest with this work.
Authorship: All authors have had access to the data and a role in the manuscript.
Identification
Copyright
© 2010 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
