Abstract
Purpose
Moderate alcohol use is part of a healthy lifestyle, yet current guidelines caution
nondrinkers against starting to drink alcohol in middle age. The purpose of this study
was to evaluate whether adopting moderate alcohol consumption in middle age would
result in subsequent lower cardiovascular risk.
Methods
This study examined a cohort of adults aged 45-64 years participating in the Atherosclerosis
Risk in Communities study over a 10-year period. The primary outcome was fatal or
nonfatal cardiovascular events.
Results
Of 7697 participants who had no history of cardiovascular disease and were nondrinkers
at baseline, within a 6-year follow-up period, 6.0% began moderate alcohol consumption
(2 drinks per day or fewer for men, 1 drink per day or fewer for women) and 0.4% began
heavier drinking. After 4 years of follow-up, new moderate drinkers had a 38% lower
chance of developing cardiovascular disease than did their persistently nondrinking
counterparts. This difference persisted after adjustment for demographic and cardiovascular
risk factors (odds ratio 0.62, 95% confidence interval, 0.40-0.95). There was no difference
in all-cause mortality between the new drinkers and persistent nondrinkers (odds ratio
0.71, 95% confidence interval, 0.31-1.64).
Conclusion
People who newly begin consuming alcohol in middle age rarely do so beyond recommended
amounts. Those who begin drinking moderately experience a relatively prompt benefit
of lower rates of cardiovascular disease morbidity with no change in mortality rates
after 4 years.
Keywords
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References
- Factors influencing the relation between alcohol and cardiovascular disease.Curr Opin Lipidol. 2006; 17: 17-21
- Prospective study of alcohol drinking patterns and coronary heart disease in women and men.BMJ. 2006; 332: 1244-1248
- Moderate wine and alcohol consumption: beneficial effects on cardiovascular disease.Thromb Haemost. 2001; 86: 517-528
- Seven-year changes in alcohol consumption and subsequent risk of cardiovascular disease in men.Arch Intern Med. 2000; 160: 2605-2612
- Alcohol consumption and risk of coronary heart disease.BMJ. 1991; 303: 211-216
- Alcohol, type of alcohol, and all-cause and coronary heart disease mortality.Ann N Y Acad Sci. 2002; 957: 16-20
- Alcohol consumption and mortality among women.N Engl J Med. 1995; 332: 1245-1250
- Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer.Ann Intern Med. 2000; 133: 411-419
- Moderate alcohol intake and motor vehicle crashes: the conflict between health advantage and at-risk use.Alcohol Alcohol. 2006; 41: 451-454
- Alcohol, wine and cardiovascular disease.(Accessed August 16, 2007)
- Alcohol, cardiovascular diseases and diabetes mellitus.Pharmacol Res. 2007; 55: 237-247
- Alcohol consumption and risk for coronary heart disease among men with hypertension.Ann Intern Med. 2007; 146: 10-19
- Alcohol intake and cardiovascular disease and mortality: the role of pre-existing disease.J Epidemiol Community Health. 2007; 61: 441-446
- Alcohol consumption and risk for coronary heart disease in men with healthy lifestyles.Arch Intern Med. 2006; 166: 2145-2150
- The atherosclerosis risk in communities (ARIC) study: design and objectives.Am J Epidemiol. 1989; 129: 687-702
- Atherosclerosis risk in communities.(Accessed January 16, 2008)
- American Heart Association (AHA) Guidelines.(Accessed August 22, 2006)
- Nutrition recommendations and interventions for diabetes—2006: a position statement of the American Diabetes Association.Diabetes Care. 2006; 29: 2140-2157
- Alcohol and atherosclerosis: recent insights.Curr Atheroscler Rep. 2007; 9: 116-124
- President’s challenge.(Accessed August 22, 2006)
- Aerobic exercise guidelines for specific goals.(Accessed August 22, 2006)
- Systematic errors in estimating mean blood pressure from finger blood pressure measurements.Blood Press. 1998; 7: 277-281
- Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women: the HALE project.JAMA. 2004; 292: 1433-1439
- Healthy lifestyle factors in the primary prevention of coronary heart disease among men.Circulation. 2006; 114: 160-167
- Healthy lifestyle and the risk of stroke in women.Arch Intern Med. 2006; 166: 1403-1409
- Alcohol and cardiovascular health: recent findings.Am J Cardiovasc Drugs. 2001; 1: 167-172
- Alcohol consumption is associated with enrichment of high-density lipoprotein particles in polyunsaturated lipids and increased cholesterol esterification rate.Alcohol Clin Exp Res. 2002; 26: 1134-1140
- Alcohol use, vascular disease, and lipid-lowering drugs.J Pharmacol Exp Ther. 2006; 318: 1-7
- Red wine increases the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects.J Am Coll Cardiol. 2003; 41: 471-478
- Moderate alcohol consumption and cancer.Ann Epidemiol. 2007; 17: S46-S48
- Epidemiology of alcohol-associated cancers.Alcohol. 2005; 35: 161-168
- Alcohol consumption and breast cancer risk in the Women’s Health Study.Am J Epidemiol. 2007; 165: 667-676
- Alcohol drinking and colorectal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population.Jpn J Clin Oncol. 2006; 36: 582-597
- Clinical guidelines for alcohol use disorders in older adults.(Accessed January 16, 2008)
- Alcohol consumption with age: a cross-sectional and longitudinal study of the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1995.Am J Epidemiol. 2001; 153: 1102-1111
- Is it necessary to correct for measurement error in nutritional epidemiology?.Ann Intern Med. 2007; 146: 65-67
Article Info
Footnotes
This research was supported by grant # R01 HL076271 from the National Heart, Lung, and Blood Institute.
Identification
Copyright
© 2008 Elsevier Inc. Published by Elsevier Inc. All rights reserved.