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Intralaboratory reliability of serologic and urine testing for Lyme disease

      Laboratory testing for Lyme disease is controversial because of problems with test sensitivity and specificity, the lack of standardized reagents, and interlaboratory and intralaboratory variability (
      • Hofmann H
      Lyme borreliosis—problems of serological diagnosis.
      ,
      • Brown S.L
      • Hansen S.L
      • Langone J.J
      Role of serology in the diagnosis of Lyme disease.
      ,
      • Bakken L.L
      • Callister S.M
      • Wand P.J
      • Schell R.F
      Interlaboratory comparison of test results for detection of Lyme disease by 516 participants in the Wisconsin State Laboratory of Hygiene/College of American Pathologists proficiency testing program.
      ,
      • Bakken L.L
      • Case K.L
      • Callister S.M
      • et al.
      Performance of 45 laboratories participating in a proficiency testing program for Lyme disease serology.
      ,
      • Luger S.W
      • Krauss E
      Serologic tests for Lyme disease. Interlaboratory variability.
      ). We determined the reliability of a serologic test and a urine test for Lyme disease, each performed in a reference laboratory, in control subjects and patients with Lyme disease who had posttreatment symptoms.
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