This paper is only available as a PDF. To read, Please Download here.
Although adverse drug reactions are a wellrecognized cause of mental status changes
in the elderly, antimicrobials are rarely implicated. Three patients with serious
organic brain disease developed paranoid psychosis after therapy with trimethoprim-sulfamethoxazole
or ciprofloxacin was begun. One of the patients was accidently rechallenged and again
developed a psychotic reaction. The acute psychoses did not improve with moderate
doses of major tranquilizers but resolved completely with drug discontinuation.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The American Journal of MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Drugs that cause psychiatric symptoms.Medical Letter. 1989; 31: 113-118
- Acute psychosis in a patient receiving trimethoprim-sulfamethaxazole intravenously.J Clin Psychiatry. 1986; 47: 269-270
- Severe depression from TMP-SMX [Letter].Drug Intell Clin Pharm. 1988; 22: 267
- Safety of oral ciprofloxacin: an update based on clinical trial results.Am J Med. 1989; 87: 98S-102S
- Brief report: safety of ciprofloxacin based on phase IV studies in the Federal Republic of Germany.Am J Med. 1989; 87: 103S-106S
- Adverse effects of quinolone antimicrobial agents.in: Wolfson JS Hooper DC Quinolone antimicrobial agents. American Society for Microbiology, Washington1989: 249-272
- Ofloxacin-induced psychosis [Letter].Br J Psychiatry. 1987; 151: 563-564
- Norfloxacin and seizures [Letter].Ann Intern Med. 1988; 109: 169-170
- Convulsions related to enoxacin [Letter].Lancet. 1985; 2: 161
- Neurological toxicity related to pefloxacin.J Antimicrob Chemother. 1988; 21: 811-812
- Ciprofloxacin and delirium [Letter].Ann Intern Med. 1970; 110: 1989
Article info
Publication history
Accepted:
August 28,
1990
Received:
June 15,
1990
Identification
Copyright
© 1991 Reed Publishing USA. Published by Elsevier Inc.
