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Abstract
An open-label, parallel comparison of loperamide hydrochloride (Imodium® A-D)
∗Imodium® A–D liquid brand loperamide hydrochloride is a registered trademark of McNeil Consumer
Products Company.
; and bismuth subsalicylate (Pepto-Bismol®)
†Pepto-Bismol® brand bismuth subsalicylate is a registered trademark of Procter & Gamble.
; was conducted using nonprescription dosages in adult students with acute diarrhea
(three or more unformed stools in the preceding 24 hours plus at least one additional
symptom of enteric infection). For the two-day study period, the daily dosage was
limited to 8 mg (40 ml) for loperamide-treated subjects and to 4.9 g for bismuth subsalicylate-treated
subjects. At these dosages, loperamide significantly reduced the average number of
unformed bowel movements relative to bismuth subsalicylate. Following the initial
dose of treatment, control of diarrhea was maintained significantly longer with loperamide
than with bismuth subsalicylate. Time to last unformed stool was significantly shorter
with loperamide than with bismuth subsalicylate. In providing overall subjective relief,
subjects rated loperamide significantly better than bismuth subsalicylate at the end
of the 24 hours. Both treatments were well tolerated, and none of the minor adverse
effects reported resulted in discontinuation of therapy. It was concluded that loperamide
is effective at a daily dosage limit of 8 mg (40 ml) for the treatment of acute nonspecific
diarrhea and provides faster, more effective relief than bismuth subsalicylate.To read this article in full you will need to make a payment
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References
- A double-blind placebo-controlled trial of loperamide (Imodium®) in acute diarrhea.J Drug Res. 1976; 2: 54-59
- A multicentre double-blind study in acute diarrhoea comparing loperamide (R18553) with two common antidiarrhoeal agents and a placebo.Curr Ther Res. 1975; 17: 263-270
- A double-blind comparative evaluation of loperamide versus diphenoxylate with atropine in acute diarrhea.Curr Ther Res. 1977; 21: 629-637
- Loperamide (R18553), a novel type of antidiarrheal agent.Arzneimittelforschung. 1974; 24: 1660-1665
- Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers' diarrhea.JAMA. 1986; 255: 757-760
Article info
Footnotes
☆This study was supported by a grant from McNeil Consumer Products Company and the National Institutes of Health, Al-23049.
Identification
Copyright
© 1990 Published by Elsevier Inc.
