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Minimal change glomerulonephropathy and interstitial infiltration with mycosis fungoides

  • Michael Allon
    Correspondence
    Requests for reprints should be addressed to Dr. Michael Allon, University of Oklahoma School of Medicine, Section of Nephrology, Department of Medicine, Veterans Administration Medical Center, 921 Northeast 13th Street, Oklahoma City, Oklahoma 73104.
    Affiliations
    Department of Medicine, Section of Nephrology, Veterans Administration Medical Center, Atlanta, Georgia, USA

    Departments of Medicine and Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
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  • Wallace G. Campbell Jr.
    Affiliations
    Department of Medicine, Section of Nephrology, Veterans Administration Medical Center, Atlanta, Georgia, USA

    Departments of Medicine and Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
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  • Sherif A. Nasr
    Affiliations
    Department of Medicine, Section of Nephrology, Veterans Administration Medical Center, Atlanta, Georgia, USA

    Departments of Medicine and Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
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  • Edmund Bourke
    Affiliations
    Department of Medicine, Section of Nephrology, Veterans Administration Medical Center, Atlanta, Georgia, USA

    Departments of Medicine and Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
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  • Jose Stoute
    Affiliations
    Department of Medicine, Section of Nephrology, Veterans Administration Medical Center, Atlanta, Georgia, USA

    Departments of Medicine and Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
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  • Jayarama Guntupalli
    Affiliations
    Department of Medicine, Section of Nephrology, Veterans Administration Medical Center, Atlanta, Georgia, USA

    Departments of Medicine and Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
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      Abstract

      The nephrotic syndrome developed in a patient with mycosis fungoides shortly after systemic involvement by his tumor occurred. Renal biopsy examination revealed atypical lymphocytic interstitial infiltration and changes consistent with minimal change glomerulonephropathy. The patient's proteinuria decreased following steroid therapy. This is the first report of an association between minimal change glomerulonephropathy and a proven T-cell malignant lymphoma. The implications are discussed with reference to the literature.
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