Death in a 56-year-old man with hyponatremia, fluid retention, and multiple cancers

        This paper is only available as a PDF. To read, Please Download here.


        Stenographic reports of weekly clinicopathologic conferences held in Barnes and Wohl Hospitals are published in each issue of the Journal. Members of the Departments of Internal Medicine, Radiology, and Pathology of the Washington University School of Medicine participate jointly in these conferences. Kenneth M. Ludmerer, M.D., and John M. Kissane, M.D., are the editors of this feature.
        To read this article in full you will need to make a payment

        Purchase one-time access:

        Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
        One-time access price info
        • For academic or personal research use, select 'Academic and Personal'
        • For corporate R&D use, select 'Corporate R&D Professionals'


        Subscribe to The American Journal of Medicine
        Already a print subscriber? Claim online access
        Already an online subscriber? Sign in
        Institutional Access: Sign in to ScienceDirect


          • Cann CI
          • Fried MP
          • Rothman KJ
          Epidemiology of squamous cell cancer of the head and neck.
          in: Symposium on squamous cell cancer of the head and neck. Otolaryngol Clin North Am. 18. 1985: 337-388
          • Rothman KJ
          • Cann CI
          • Flanders W
          • et al.
          Epidemiology of laryngeal cancer.
          Epidemiol Rev. 1980; 2: 195-209
          • Tuyns AJ
          • Audigier JC
          Double wave cohort increase for oesophageal and laryngeal cancer in France in relation to reduced alcohol consumption during the Second World War.
          Digestion. 1976; 14: 197-208
          • Silverberg E
          Cancer statistics.
          Cancer J Clin. 1984; 34: 7-23
        1. Young JL, Percy CL, Asire AJ, eds: Surveillance, epidemiology, and end results: incidence and mortality data, 1973–1977. National Cancer Institute Monograph 57, National Institutes of Health, Public Health Service (DHHR publication no [NIH] 81–2330).

          • Easton JM
          • Levine PH
          • Connelly RR
          • et al.
          Studies on nasopharyngeal carcinoma in the United States: a model for international comparisons.
          Comp Immunol Microbiol Infect Dis. 1979; 2: 221-228
          • Dreher KF
          • Fraser JG
          Smoking habits of alcoholic outpatients.
          Int J Addict. 1967; 2: 259-270
          • Herity B
          • Moriarty M
          • Bourke GJ
          • et al.
          A case-control study of head and neck cancer in the Republic of Ireland.
          Br J Cancer. 1981; 43: 177-182
          • Keller AZ
          • Terris M
          The association of alcohol and tobacco with cancer of the mouth and pharynx.
          Am J Public Health. 1965; 55: 1578-1585
          • Martinez I
          Factors associated with cancer of the esophagus, mouth, and pharynx in Puerto Rico.
          JNCI. 1969; 42: 1069-1094
          • Wynder EL
          • Bross IJ
          A study of etiological factors in cancer of the esophagus.
          Cancer. 1961; 14: 389-413
          • Wynder EL
          • Stellman SD
          Comparative epidemiology of tobacco-related cancers.
          Cancer Res. 1977; 37: 4608-4622
          • American Cancer Society
          Cancer facts and figures.
          American Cancer Society, New York1982
          • Winawer SJ
          • Sherlock P
          • Schottenfield D
          • et al.
          Screening for colon cancer.
          Gastroenterology. 1976; 70: 783-789
          • Schottenfeld D
          • Winawer SJ
          Large intestine.
          in: Schottenfeld D Fraumeni Jr., J Cancer epidemiology and prevention. WB Saunders, Philadelphia1982: 703-727
          • Winawer SJ
          • Miller DG
          • Sherlock P
          Risk and screening for colorectal cancer.
          in: Yearbook Medical Publishers, Chicago1984: 471-496
          • Weisberger JH
          • Reddy SS
          • Spingarn NE
          • et al.
          Winawer SJ Schottenfeld D Sherlock P Current views on the mechanisms involved in the etiology of colorectal cancer. Progress in cancer research and therapy, vol 13: Colorectal cancer: prevention, epidemiology and screening. Raven Press, New York1980: 19-41
          • Tollefson L
          The use of epidemiology, scientific data, and regulatory authority to determine risk factors in cancer of some organs of the digestive system. 4. Colon cancer.
          Regul Toxicol Pharmacol. 1986; 6: 24-54
          • Million RR
          • Cassisso NJ
          Million RR Cassisso NJ Management of head and neck cancer. A multi-disciplinary approach. JB Lippincott, Philadelphia1984: 29-35
          • Million RR
          • Cassisso NJ
          Million RR Cassisso NJ Management of head and neck cancer. A multi-disciplinary approach. JB Lippincott, Philadelphia1984: 63-97
          • Fazell EL
          • Lucias JC
          Cancer of the tongue; report of the management of 1,554 patients.
          Cancer. 1967; 15: 1085-1099
          • Lee JG
          • Krause CJ
          Radical neck dissection: elective therapeutic and secondary.
          Arch Otol. 1975; 101: 656-659
          • Johnson JT
          • Barnes EL
          • Myers EN
          • Schram VL
          • Borochovitz D
          • Sigler BA
          Extra-capsular spread of tumors in cervical node metastasis.
          Arch Otol. 1981; 107: 725-729
          • Norris CM
          • Clark JR
          • Frei E
          • et al.
          Pathology of surgery after induction chemotherapy: an analysis of resectability and locoregional control.
          Laryngoscope. 1986; 96: 292-302
          • McGregor IA
          • McGregor FM
          Cancer of the face and mouth.
          in: Churchill Livingston, Edinburgh1986: 478
          • Kish JA
          • Weaver A
          • Jacobs J
          • et al.
          Cisplatin and 5-fluorouracil infusion in patients with recurrent and disseminated epidermoid cancer of the head and neck.
          Cancer. 1984; 53: 1819-1824
          • Crile GW
          Carcinoma of the jaws, tongue, cheek and lips.
          Surg Gynecol Obstet. 1923; 36: 159-184
          • Merino OR
          • Lindberg RD
          • Fletcher GH
          An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tracts.
          Cancer. 1977; 40: 145-151
          • Shapshay S
          • Wong WK
          • Fried M
          • Strong S
          Simultaneous carcinomas of the esophagus and upper aerodigestive tract.
          Otolaryngol Head Neck Surg. 1980; 88: 373-377
          • Olson RM
          • Perencovich NP
          • Malcom AW
          • Chaffey JT
          • Wilson RE
          Patterns of recurrence following curative resection of adenocarcinoma of the colon and rectum.
          Cancer. 1980; 45: 2669-2675
          • Chung HM
          • Klug R
          • Schrier RW
          • Anderson RJ
          Postoperative hyponatremia.
          Arch Intern Med. 1986; 146: 333-336
          • Schwartz W
          • Bennet N
          • Curelops S
          • et al.
          A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of anti-diuretic hormones.
          Am J Med. 1957; 23: 529-542
          • DeTroyer A
          • Demanet JC
          Clinical, biological, and pathologic features of the syndrome of inappropriate secretion of anti-diuretic hormone.
          Q J Med. 1976; 180: 521-533
          • Davies MG
          Pneumonia causing the syndrome of inappropriate secretion of anti-diuretic hormones.
          Br J Clin Pract. 1974; 31: 82-84
          • Spanos A
          • Christopher JS
          Inappropriate secretion of antidiuretic hormone with chronic chest infections.
          Br Med J. 1974; 3: 785-786
          • Cain JL
          Clinical aspects of inappropriate secretion of antidiuretic hormone.
          J Indiana State Med Soc. 1970; 63: 430-482
          • Abeloff MD
          • Eggleston JC
          • Mendelsohn G
          • Ettinger DS
          • Baylin SB
          Changes in morphologic and biochemical characteristics of small cell carcinoma of the lung.
          Am J Med. 1979; 66: 757-764
          • Hande UR
          • Des Prez RM
          Current perspectives in small cell lung cancer.
          Chest. 1984; 85: 669-677
          • Carney DN
          Recent advances in the biology of small cell lung cancer.
          Chest. 1986; 89 (suppl): 253-257