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Abstract
Seventy-four patients with Raynaud's phenomenon and no associated illness were followed
prospectively to determine whether a secondary disease would develop, and clinical
and laboratory assessments were performed at study entry to determine their association
with the subsequent development of disease. After an average of 2.7 years of follow-up
(range 0.5 to 5.7 years), outcome information was available on 58 persons (78.4 percent).
A connective tissue disease developed in 11 (19.0 percent): three systemic sclerosis
and eight CREST syndrome. The two variables at entry most strongly associated with
the subsequent development of a connective tissue disease were an abnormal nailfold
capillary pattern (adjusted odds ratio = 26.82, 95 percent confidence Interval= 4.69,
153.2) and an abnormal pulmonary function test result (odds ratio = 4.78, 95 percent
confidence interval = 1.02, 22.41). The positive association of an abnormal barium
esophagram, presence of antinuclear antibodies, and cutaneous abnormalities did not
reach statistical significance. The development of connective tissue diseases in this
group of patients is not rare. An abnormal nailfold capillary pattern is strongly
associated with the subsequent development of systemic sclerosis or CREST syndrome
in patients with Raynaud's phenomenon.
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Article info
Publication history
Accepted:
January 25,
1988
Received:
September 29,
1987
Footnotes
☆This work was supported in part by National Institutes of Health Clinical Research Center Grant RR-0068-18 and a grant from the Ohio Department of Health.
Identification
Copyright
© 1988 Published by Elsevier Inc.
