Immunologic study of human encephalitic and paralytic rabies

Preliminary report of 16 patients
      This paper is only available as a PDF. To read, Please Download here.


      Lymphocyte proliferation tests to rabies antigen and myelin basic protein were performed on peripheral blood lymphocytes from nine patients with the encephalitic form and on seven with the paralytic form of human rabies. Six of the nine patients with encephalitis had proliferative responses to rabies antigen, whereas all of the patients with paralysis had no response. Two patients in each group also had a proliferative response to myelin basic protein. The myelin basic protein-reactive patients had a more rapidly fatal disease than the nonreactive patients. This preliminary study suggests that host immune responses may influence the clinical manifestations and course in human rabies.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Smith JS
        • McClelland CL
        • Reid FL
        • Baer GM
        Dual role of the immune response in street rabies virus infection of mice.
        Infect Immun. 1982; 35: 213-221
        • Iwasaki Y
        • Gerhard W
        • Clark HF
        Role of host immune response in the development of either encephalitic or paralytic disease after experimental rabies infection in mice.
        Infect Immun. 1977; 18: 220-225
        • Tignor GH
        • Shope RE
        • Gershon RK
        • Waksman BH
        Immunopathologic aspects of infection with Lagos bat virus of the rabies serogroup.
        J Immunol. 1974; 112: 260-265
        • Prabhakar BS
        • Nathanson N
        Acute rabies death mediated by antibody.
        Nature. 1981; 290: 590-591
        • Held JR
        • Tierkel ES
        • Steele JH
        Rabies in man and animals in the United States, 1946–1965.
        Public Health Rep. 1967; 82: 1009-1018
      1. Epidemiological surveillance report, Thailand.

        • Smith JS
        • Yager PA
        • Bear GM
        A rapid reproducible test for determining rabies neutralizing antibody.
        Bull WHO. 1973; 48: 535-541
        • Ratanavongsiri J
        • Sriwanthana B
        • Ubol S
        • Phanuphak P
        Cell-mediated immune response following intracutaneous immunisation with human diploid cell rabies vaccine.
        Asian J Allergy Immunol. 1985; 3: 187-190
        • Hemachudha T
        • Griffin DE
        • Giffels JJ
        • Johnson RT
        • Moser AB
        • Phanuphak P
        Myelin basic protein as an encephalitogen in encephalomyelitis and polyneuritis following rabies vaccination.
        N Engl J Med. 1987; 316: 369-374
        • Hemachudha T
        • Phanthumchinda K
        • Phanuphak P
        • Manutsathit S
        Myoedema as a clinical sign in paralytic rabies.
        Lancet. 1987; I (letter): 1210
        • Baer GM
        Rabies virus.
        in: Fields BN Virology. Raven Press, New York1985: 1133-1156
        • Chopra JS
        • Banerjee AK
        • Murthy JMK
        • Pal SR
        Paralytic rabies.
        in: A clinico-pathological study. 9th ed. Brain. 103. 1980: 789-802
        • Hurst EW
        • Pawan JL
        An outbreak of rabies in Trinidad without history of bites and with the symptoms of acute ascending myelitis.
        Lancet. 1931; II: 622-628
        • Hurst EW
        • Pawan JL
        A further account of the Trinidad outbreak of acute rabies myelitis: histology of the experiment disease.
        J Pathol Bacteriol. 1932; 35: 301-321
        • Knutti RE
        Acute ascending paralysis and myelitis due to the virus of rabies.
        JAMA. 1929; 93: 754-758
        • Tangchai P
        • Yenbutr D
        • Vejjajiva A
        Central nervous system lesions in human rabies—a study of 24 autopsy cases.
        J Med Assoc Thailand. 1970; 53: 471-488
        • Love SV
        Paralytic rabies.
        in: Review of literature and report of a case. 9th ed. J Pediatr. 24. 1944: 312-325
        • Vejjajiva A
        • Tamthai B
        Human rabies.
        in: An analysis of 152 cases. 9th ed. J Med Assoc Thailand. 50. 1967: 796-800
        • Johnson RT
        • Griffin DE
        • Hirsch RL
        • et al.
        Measles encephalomyelitis—clinical and immunologic studies.
        N Engl J Med. 1984; 310: 137-141
        • Hemachudha T
        • Phanuphak P
        • Johnson RT
        • Griffin DE
        • Ratanavongsiri J
        • Siriprasomsup W
        Neurological complications of Semple type post-exposure rabies immunization: clinical and immunological studies.
        Neurology. 1987; 37: 550-556
        • Lisak RP
        • Zweiman B
        In vitro cell-mediated immunity of cerebrospinal-fluid lymphocytes to myelin basic protein in primary demyelinating diseases.
        N Engl J Med. 1977; 297: 850-853