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Abstract
Fifty-eight women with postmenopausal osteoporosis (crush fracture of the spine) were
compared with 58 age-matched normal women. The osteoporosic women had lower total-body
calcium levels and bone mineral content of the radius, had undergone an earlier menopause,
smoked cigarettes more, and had breast-fed less often. They also had lower levels
of estrone, estradiol, and testosterone and reduced levels of 25-hydroxyvitamin D,
24,25-dihydroxyvitamin D, and 1,25-dihydroxyvitamin D. These findings suggest the
presence of changeable risk factors for the development of osteoporosis. Smoking should
be discouraged. An adequate intake of calcium and vitamin D should be ensured. It
is the opinion of the authors that those women who have had an early menopause or
who have a low bone mass at the time of menopause should be given the choice of medically
supervised replacement therapy with estrogen and progesterone.
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Article Info
Publication History
Accepted:
July 19,
1984
Footnotes
☆This work was supported in part by Contracts EY-76-C-02-0016 and DE-AC02-76CH00016 from the United States Department of Energy. Calcium studies were supported by National Institutes of Health Grant 1-R01-AG-009 19-04.
Identification
Copyright
© 1985 Published by Elsevier Inc.
