Comparison of morning and evening dosing with a 24-hour sustained-release theophylline, Uniphyl, for nocturnal asthma

  • William W. Busse
    Requests for reprints should be addressed to Dr. William W. Busse, Section of Allergy and Clinical Immunology, University of Wisconsin Medical School, Madison, Wisconsin 53792.
    Department of Medicine, University of Wisconsin, and the William S. Middleton Veterans Hospital, Madison, Wisconsin, USA
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  • Robert K. Bush
    Department of Medicine, University of Wisconsin, and the William S. Middleton Veterans Hospital, Madison, Wisconsin, USA
    Search for articles by this author
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      Sixteen adults who had chronic asthma with nocturnal symptoms were selected to evaluate and compare the effectiveness of 7 A.M. versus 7 P.M. single daily dosing with the 24-hour sustained-release theophylline Uniphyl. The study was a randomized, double-blind, placebo-controlled trial in which the patients were given 800 mg of Uniphyl at either 7 A.M. or 7 P.M. for one week each. Serum theophylline levels showed significantly higher peak (18.1 ± 1.8 μg/ml versus 12.7 ± 1.2 μg/ml) and trough (12.4 ± 1.3 μg/ml versus 7.6 ± 1.0 μg/ml) concentrations during evening dosing. Furthermore, daily peak flow values were higher in the morning when Uniphyl was given at 7 P.M. Thus, nocturnal dosing with Uniphyl gives higher serum theophylline concentrations and, with this, better control of nocturnal asthma.
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