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Effects of methylxanthines on airway mucociliary function

  • Adam Wanner
    Correspondence
    Requests for reprints should be addressed to Dr. Adam Wanner, Division of Pulmonary Disease, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, Florida 33140.
    Affiliations
    Pulmonary Division, Department of Medicine, University of Miami School of Medicine at Mount Sinai Medical Center, Miami Beach, Florida, USA
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      Abstract

      Mucociliary interaction and hence mucus clearance in the airways is governed by ciliary activity and the depth and rheologic properties of periciliary fluid and mucus. Therefore, a defect in one or more of these component functions must be responsible for the impairment of mucociliary clearance in patients with a variety of airway diseases. Methylxanthines stimulate ciliary beat frequency, augment net ion secretion with a substantial increase in water flux toward the lumen, and promote mucus secretion in the lower airways. The net result is an enhancement of mucociliary clearance. This beneficial action of methylxanthines on mucociliary function may complement their effects on bronchoconstriction and respiratory muscle dysfunction in patients with chronic bronchitis, cystic fibrosis, and bronchial asthma.
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      References

        • Wanner A
        Clinical aspects of mucociliary transport.
        Am Rev Respir Dis. 1977; 116: 73-125
        • Ross SM
        • Corrsin S
        Results of an analytical model of mucociliary pumping.
        J Appl Physiol. 1974; 37: 333-340
        • Serafini SM
        • Wanner A
        • Michaelson ED
        Mucociliary transport in central and intermediate size airways: effect of aminophylline.
        Bull Physiopath Resp. 1976; 12: 415-418
        • Wolff RK
        • Dolovich MB
        • Obminski G
        • et al.
        Effects of exercise and eucapnic hyperventilation on bronchial clearance in man.
        J Appl Physiol. 1977; 43: 46-50
        • King M
        Interrelation between mechanical properties of mucus and mucociliary transport: effect of pharmacologic interventions.
        Biorheology. 1979; 16: 57-68
        • Camner P
        • Mossberg B
        • Afzelius BA
        Evidence for congenitally nonfunctioning cilia in the tracheobronchial tract in two subjects.
        Am Rev Respir Dis. 1975; 112: 807-809
        • Gibbons IR
        An effect of adenosine triphosphate on the light scattered by suspensions of cilia.
        J Cell Biol. 1965; 26: 707
        • Saavedra S
        • Renaud F
        Studies on reactivated cilia.
        Exp Cell Res. 1975; 90: 439
        • Usuki I
        Effect of adenosine triphosphate on the ciliary activity and its histochemical demonstration in the oyster gill.
        Sci Rep Res Inst Tohoku Univ [Biol]. 1959; 25: 65
        • Alexandrov VY
        • Arronet NM
        Motion caused by adenosine triphosphate of cilia in ciliated epithelium killed by glycerol extraction (a cellular model).
        Dokl Akad Nauk USSR. 1956; 110: 457
        • Borhaus EF
        • Deyrup IJ
        The effect of adenosine triphosphate on the cilia of the pharyngeal mucosa of the frog.
        Science. 1953; 92: 553
      1. Kilburn KH Salzano JV Symposium on structure, function and measurement of respiratory cilia. 6th ed. Am Rev Respir Dis. 93. 1966: 184 (part 2)
        • Nelson DJ
        • Wright EM
        The distribution, activity and function of the cilia in the frog brain.
        J Physiol. 1974; 243: 63-78
        • Ai-Bazzaz FJ
        Role of cyclic AMP in regulation of chloride secretion by canine tracheal mucosa.
        Am Rev Respir Dis. 1981; 123: 295-298
        • Whimster WF
        • Reid L
        The influence of dibutyryl cyclic adenosine monophosphate and other substances on human bronchial mucous gland discharge.
        Exp Mol Pathol. 1973; 18: 234-240
        • Wanner A
        Pulmonary secretions.
        Semin Resp Med. 1984; 5: 301-359
        • Hers JF
        • Masurel N
        • Mulder J
        Bacteriology and histopathology of the respiratory tract and lungs in fatal Asian influenza.
        Lancet. 1958; II: 1141
        • Biberfeld C
        • Biberfeld P
        Ultrastructural features of Mycoplasma pneumoniae.
        J Bactriol. 1970; 102: 855
        • Wright RR
        • Stuart CM
        Chronic bronchitis with emphysema: a pathological study of the bronchi.
        Med Thorac. 1975; 22: 210
        • Kleinerman J
        • Boren HG
        Morphologic basis of chronic obstructive lung disease.
        in: Baum GL Textbook of pulmonary disease. Little, Brown, Boston1974: 571
        • Esterly JR
        • Openheimer EH
        Observations in cystic fibrosis of the pancreas. III. Pulmonary lesions.
        Johns Hopkins Med J. 1968; 122: 94
        • Dunnill MS
        • Massarella GR
        • Anderson JA
        A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema.
        Thorax. 1969; 24: 176-179
        • Reid L
        The pathology of emphysema.
        in: Year Book Medical, Chicago1967: 159
        • Kitching JA
        On the activity of protozoa at low oxygen tensions.
        J Cell Comp Physiol. 1939; 14: 227
        • Zuelzer WW
        • Newton WA
        The pathogenesis of fibrocystic disease of the pancreas.
        Pediatrics. 1949; 4: 53
        • Cutz E
        • Levison H
        • Cooper DM
        Ultrastructure of airways in children with asthma.
        Histopath. 1978; 2: 407-421
        • Dulfano MJ
        • Adler KB
        Physical properties of sputum. VII. Rheologic properties and mucociliary transport.
        Am Rev Respir Dis. 1975; 112: 341-348
        • Feather EA
        • Russel G
        Sputum viscosity in cystic fibrosis of the pancreas and other pulmonary diseases.
        Br J Dis Chest. 1970; 64: 192
        • Charman J
        • Reid L
        Sputum viscosity in chronic bronchitis, bronchiectasis, asthma, and cystic fibrosis.
        Biorheology. 1972; 9: 185-199
        • Dulfano MJ
        • Luk CK
        Sputum and ciliary inhibition in asthma.
        Thorax. 1982; 37: 646-651
        • Williams IP
        • Rich B
        • Richardson PS
        Action of serum on the output of secretory glycoproteins from human bronchi in vitro.
        Thorax. 1983; 38: 682-685
        • Allegra L
        • Abraham WM
        • Chapman GA
        • Wanner A
        Duration of mucociliary dysfunction following antigen challenge in allergic sheep.
        J Appl Physiol. 1983; 55: 726-730
        • Mezey RJ
        • Cohn MA
        • Fernandez RJ
        • Januszkiewicz AJ
        • Wanner A
        Mucociliary transport in allergic patients with antigen-induced bronchospasm.
        Am Rev Respir Dis. 1978; 118: 677-684
        • Ahmed T
        • Greenblatt DW
        • Birch S
        • Marchette B
        • Wanner A
        Abnormal mucociliary transport in allergic patients with antigen-induced bronchospasm: role of SRS-A.
        Am Rev Respir Dis. 1981; 124: 110-114
        • Russi E
        • Chapman GA
        • Marchette B
        • Abraham WM
        • Wanner A
        Effects of leukotriene D4 on mucociliary function and airway mechanics in allergic sheep.
        Am Rev Respir Dis. 1983; 127: 70
        • Persson CGA
        • Karlsson JA
        • Erjefalt I
        Differentiation between bronchodilation and universal adenosine antagonism among xanthine derivatives.
        Life Sci. 1982; 30: 2181-2189
        • Kolbeck RC
        • Speir WA
        • Carrier GO
        • Bransome ED
        Apparent irrelevance of cyclic nucleotides to the relaxation of tracheal smooth muscle induced by theophylline.
        Lung. 1979; 156: 173-183
        • Iravani J
        • Melville GN
        Wirkung von Pharmaka und Milicuanderungen auf die Flimmertatigkeit der Atemwege.
        Respiration. 1975; 32: 157
        • Konietzko N
        • Nakhosteen JA
        • Mizera W
        • et al.
        Ciliary beat frequency of biopsy samples taken from normal persons and patients with various lung diseases.
        Chest. 1981; 80: 855-857
        • Welsh MJ
        • Widdicombe JH
        • Nadel JA
        Fluid transport across the canine tracheal epithelium.
        J Appl Physiol. 1980; 49: 905-909
        • Al-Bazzaz FJ
        • Al-Awqati Q
        Interaction between sodium and chloride transport in canine tracheal mucosa.
        J Appl Physiol. 1979; 46: 111-119
        • Matthys H
        • Kohler D
        Effect of theophylline on mucociliary clearance in man.
        Eur J Respir Dis. 1980; 61: 98-102
        • Matthys H
        • Vastag E
        • Daikeler G
        • Kohler D
        The influence of aminophylline and pindolol on the mucociliary clearance in patients with chronic bronchitis.
        Br J Clin Pract. 1983; : 10-15
        • Sutton PP
        • Pavia D
        • Bateman JRM
        • Clarke SW
        The effect of oral aminophylline on lung mucociliary clearance in man.
        Chest. 1981; 80: 889-892
        • Whiteside ME
        • Lauredo I
        • Chapman GA
        • Ratzan KR
        • Abraham WM
        • Wanner A
        Effect of atropine on tracheal bacterial counts.
        Bull Eur Physiopath Resp. 1984; 29: 347-351