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HLA-B27-associated heart disease

Clinicopathologic study of three cases
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      Abstract

      The histologic features of the cardiac lesions in HLA-B27-associated heart disease were examined in three cases that illustrate different nuances of the clinical spectrum of this disorder. One of these cases constitutes an important link between the previously established concept of cardiac manifestations in ankylosing spondylltis and Reiter's disease and the recently introduced, wider concept of HLA-B27-associated cardiac manifestations. A correlation between the invasive electrophysiologic results and the autopsy findings is demonstrated in another case.
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      References

        • Bernstein L
        • Broch OJ
        Cardiac complications in spondylarthritis ankylopoietica.
        Acta Med Scand. 1949; 135: 185-194
        • Graham DC
        • Smythe HA
        The carditis and aortitis of ankylosing spondylitis.
        Bull Rheum Dis. 1958; 9: 171-174
        • Good AE
        Reiter's disease: a review with special attention to cardiovascular and neurologic sequellae.
        in: Semin Arthritis Rheum. 3. 1974: 253-286
        • Bulkley BH
        • Roberts WC
        Ankylosing spondylitis and aortic regurgitation: description of the characteristic cardiovascular lesion from study of eight necropsy patients.
        Circulation. 1973; 48: 1014-1027
        • Bergfeldt L
        • Edhag O
        • Vedin L
        • Vallin H
        Ankylosing spondylitis: an important cause of severe disturbances of the cardiac conduction system. Prevalence among 223 pacemakertreated men.
        Am J Med. 1982; 73: 187-191
        • Bergfeldt L
        HLA B27-associated rheumatic diseases with severe cardiac bradyarrhythmias. Clinical features in 223 men with permanent pacemakers.
        Am J Med. 1983; 75: 210-215
        • Bergfeldt L
        • Möller E
        Complete heart block—another HLAB27-associated disease manifestation.
        Tissue Antigens. 1983; 21: 385-390
        • Bergfeldt L
        • Vallin H
        • Edhag O
        Complete heart block in HLA B27-associated disease. Electrophysiological and clinical characteristics.
        Br Heart J. 1984; 51: 184-188
        • Bergfeldt L
        • Edhag O
        • Vallin H
        Cardiac conduction disturbances, an underestimated manifestation in ankylosing spondylitis. A 25-year follow-up study of 68 patients.
        Acta Med Scand. 1982; 212: 217-223
        • Gofton JP
        • Bennett PH
        • Bremner JM
        • et al.
        Report from the subcommittee on diagnostic criteria for ankylosing spondylitis.
        in: Bennett PH Wood PNH Population studies of the rheumatic diseases. Excerpta Medica Foundation, Amsterdam1968: 314-316
        • Gofton JP
        • Bennett PH
        • Bremner JM
        • et al.
        Report from the subcommittee on diagnostic criteria for ankylosing spondylitis.
        in: Bennett PH Wood PNH Population studies of the rheumatic diseases. Excerpta Medica Foundation, Amsterdam1968: 456-457
        • Toone Jr, EC
        • Pierce EL
        • Hennigar GR
        Aortitis and aortic regurgitation associated with rheumatoid spondylitis.
        Am J Med. 1959; 26: 255-263
        • Davidson P
        • Baggenstoss AH
        • Slocumb CH
        • Daugherty GW
        Cardiac and aortic lesions in rheumatoid spondylitis.
        in: Proc Staff Meet Mayo Clin. 38. 1963: 427-435
        • Roberts WC
        • Hollingsworth JF
        • Bulkley BH
        • Jaffe RB
        • Epstein SE
        • Stinson EB
        Combined mitral and aortic regurgitation in ankylosing spondylitis. Angiographic and anatomic features.
        Am J Med. 1974; 56: 237-243
        • Harvey DB
        • Hollenberg M
        • Kunkel F
        • Scheinman MM
        Ankylosing spondylitis with complete heart block.
        Arch Intern Med. 1976; 136: 1046-1050
        • Rossen RM
        • Goodman DJ
        • Harrison DC
        A-V conduction disturbances in Reiter's syndrome.
        Am J Med. 1975; 58: 280-284
        • Nitter-Hauge S
        • Otterstad JE
        Characteristics of atrioventricular conduction disturbances in ankylosing spondylitis (Mb Bechterew).
        Acta Med Scand. 1981; 210: 197-200
        • Takkunen J
        • Voupala U
        • Isomäki H
        Cardiomyopathy in ankylosing spondylitis: part I. Medical history and results of clinical examination in a series of 55 patients.
        Ann Clin Res. 1970; 2: 106-112
        • Morley KD
        • Ribeiro PA
        • Garnett RAF
        • Goodwin JF
        • Hughes GRV
        Left ventricular function in patients with ankylosing spondylitis and Reiter's disease (abstr). The Heberden Round.
        Hammersmith Hospital, London1982
        • Moll MH
        • Haslock I
        • Macrae IF
        • Wright V
        Associations between ankylosing spondylitis, psoriatic arthritis, Reiter's disease, the intestinal arthropathies, and Behcet's syndrome.
        Medicine (Baltimore). 1974; 53: 343-364
        • Wright V
        Relationships between ankylosing spondylitis and other spondarthritides.
        in: Moll JMH Ankylosing spondylitis. Churchill Livingstone, New York1980: 42-51