Advertisement

Neurocrest and colonic tumors: New clinical syndrome

Report of three cases
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      This report describes three patients with both multiple intestinal polyps and tumors of neural crest origin. This combination of findings may represent a new clinical syndrome. The embryologic relationships between tumors derived from endoderm and tumors derived from neurocrest are described. An inherent defect in tissue proliferation or repair is postulated to explain the abnormal growth in these two different cell lines.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Upton AC
        Principles of cancer biology: etiology and prevention of cancer.
        in: DeVita Jr, VT Hellman S Rosenberg SA Cancer: principles and practice of oncology. JB Lippincott, Philadelphia1982: 34-35
        • Naylor EW
        • Gardner E
        Penetrance and expressivity of the gene responsible for the Gardner syndrome.
        Clin Genet. 1977; 11: 381-383
        • Takor TT
        • Pierce AG
        Neuroectodermal origin of the avian hypothalamo-hypophyseal complex: the role of the ventral neural ridge.
        J Embryol Exp Morphol. 1975; 34: 311-325
        • Le Douarin N
        Migration and differentiation of neurocrest cells.
        Current Studies in Developmental Biology. 1980; 16: 31-85
        • Ulich TR
        • Cheng L
        • Glover H
        • Yang K
        • Lewin KJ
        A colonic adenocarcinoma with argentaffin cells.
        Cancer. 1983; 51: 1483-1489
        • Li FP
        • Little JB
        • Bech-Hansen NT
        • et al.
        Acute leukemia after radiotherapy in a patient with Turcot's syndrome.
        Am J Med. 1983; 74: 343-348
        • Schneider NR
        • Cubilla AL
        • Chaganti RSK
        Association of endocrine neoplasms with multiple polyps of the colon.
        Cancer. 1980; 51: 1171-1175
        • Herald RJ
        Gardner's syndrome in association with two tumors of the ileum.
        in: 4th ed. Proc R Soc Med. 60. 1967: 914
        • Keshgegian AA
        • Enterline HT
        Gardner's syndrome with duodenal adenomas, gastric adenomyoma, and thyroid papillary-follicular adenocarcinoma.
        Dis Colon Rectum. 1978; 21: 255-260