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Abstract
This report reviews the 100 most recently approved drugs in order to quantify the
frequency with which post-marketing studies of drug efficacy can be performed experimentally
and non-experimentally. These drugs represent 131 potential drug uses. Of them, the
absolute efficacy of 89 (68 percent) could be evaluated from clinical observations.
Of the remaining 42, six (14 percent) could be studied experimentally or non-experimentally,
six (14 percent) only experimentally, one (2 percent) only non-experimentally, and
29 (69 percent) by neither technique. Answers to all questions of relative efficacy
required formal research. Of these, 94 (72 percent) could be studied using either
experimental or non-experimental techniques. The remaining 37 (28 percent) could be
studied experimentally only. Thus, clinical observations and non-experimental research
can contribute a large proportion of the information about drug efficacy still needed
after marketing.
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Article Info
Publication History
Accepted:
April 4,
1984
Footnotes
☆This work was supported by a grant from the Joint Commission on Prescription Drug Use, by National Institutes of Health Training Grant GM-07546, and by grants from the Charles A. Dana Foundation, the Rockefeller Foundation, and the Andrew W. Mellon Foundation.
Identification
Copyright
© 1984 Published by Elsevier Inc.
