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Effect of coffee and cigarette smoking on the blood pressure of untreated and diuretic-treated hypertensive patients

  • Author Footnotes
    1 From the University Department of Therapeutics, Royal Hallamshire Hospital, Sheffield, United Kingdom.
    Stephen Freestone
    Footnotes
    1 From the University Department of Therapeutics, Royal Hallamshire Hospital, Sheffield, United Kingdom.
    Affiliations
    Sheffield, United Kingdom
    Search for articles by this author
  • Author Footnotes
    1 From the University Department of Therapeutics, Royal Hallamshire Hospital, Sheffield, United Kingdom.
    Lawrence E. Ramsay
    Correspondence
    Requests for reprints should be addressed to Dr. Lawrence E. Ramsay, University Department of Therapeutics, Royal Hallamshire Hospital, Glossop Road, Sheffield, United Kingdom.
    Footnotes
    1 From the University Department of Therapeutics, Royal Hallamshire Hospital, Sheffield, United Kingdom.
    Affiliations
    Sheffield, United Kingdom
    Search for articles by this author
  • Author Footnotes
    1 From the University Department of Therapeutics, Royal Hallamshire Hospital, Sheffield, United Kingdom.
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      Abstract

      Patients with mild hypertension who habitually smoked cigarettes and consumed caffeine were examined after they abstained from caffeine and cigarettes overnight. Their mean blood pressure (147/89 mm Hg) was substantially lower than values recorded in the clinic (164/102 mm Hg) and remained so when they continued to abstain (149/94 mm Hg at two hours). Smoking two cigarettes (3.4 mg nicotine) elevated blood pressure by 10/8 mm Hg, but for only 15 minutes. Drinking coffee (200 mg caffeine) elevated blood pressure by up to 10/7 mm Hg between one and two hours. Combined coffee ingestion and cigarette smoking caused a sustained rise in blood pressure from 5 to 120 minutes to levels similar to those measured in the clinic (162/102 mm Hg at two hours). Similar results were obtained in thiazide-treated patients. The interaction of coffee and cigarettes on blood pressure, but not on pulse rate, was significant. The pressor effect of cigarette smoking and caffeine ingestion in combination may be important in the evaluation of patients with mild hypertension.
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