Zoster encephalitis

Isolation of virus and measurement of varicella-zoster-specific antibodies in cerebrospinal fluid
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      Varicella-zoster virus (VZV) was isolated on two occasions from the cerebrospinal fluid of an elderly woman with encephalomyeiltis complicating thoracic zoster. Antibodies to VZV-induced membrane antigen (FAMA) were present in cerebrospinal fluid in a titer of 1:64; serum antibodies were 64-fold higher. Further evidence for local antibody production was derived from simultaneous measurements of immunoglobulin G and albumin in cerebrospinal fluid and serum and calculation of a cerebrospinal fluid-IgG index.
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