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Abstract
Polymorphonuclear leukocyte functions were studied in 92 patients with protein-calorie
malnutrition. Serum folic acid levels were higher than 3 ng/ml in 38 patients and
3 ng/ml or less in 54 patients. Significant differences were found between these two
groups of patients with regard to phagocytosis (81.5 ± 1.9 versus 69.2 ± 2.0 percent,
p < 0.001) and bactericidal ability (90.6 ± 1.1 versus 84.5 ± 2.3 percent, p < 0.05).
Correction of folic acid deficiency in 22 patients was associated with recovery of
normal phagocytosis (p < 0.001) but not bactericidal function. Adding folic acid to
the serum of eight patients also restored normal phagocytic function (p < 0.001).
A correlation was found in vivo and in vitro between changes over time in folic acid
levels and in phagocytosis.
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References
- Malnutrition in surgical patients: an unrecognised problem.Lancet. 1972; II: 106-108
- Prevalence of malnutrition in general medical patients.JAMA. 1976; 235: 1567-1570
- Thymolymphatic deficiency and depression of cell-mediated immunity in protein-calorie malnutrition.Lancet. 1971; II: 939-943
- Mechanisms of defective delayed cutaneous hypersensitivity in children with protein-calorie malnutrition.Lancet. 1973; II: 506-508
- The phagocyte in protein-calorie malnutrition: a review.in: Suskind RM Malnutrition and the immune response. Raven Press, New York1977: 231-244
- Folic acid deficiency in patients under intensive care.Crit Care Med. 1981; 9: 219
- The assessment of the nutritional status of the community.Geneva: WHO Monograph Series. 1966; : 53
- Therapeutic index of nutritional depletion in hospitalized patients.Surg Gynecol Obstet. 1975; 141: 512-516
- Leukocyte oxydase: defective activity in chronic granulomatous disease.Science. 1967; 155: 835-836
- A newly defined X-linked trait in man with demonstration of the Lyon effect in carrier females.Lancet. 1967; II: 737-739
- Inhibition of granulocyte adherence by ethanol, prednisone, and aspirin, measured with an assay system.N Engl J Med. 1974; 291: 642-646
- Neutrophil leukocyte function tests.in: Thompson RA Techniques in clinical immunology. Blackwell Scientific, Oxford1977: 201-212
- A modified method for chemotaxis under agarose.J Immunol Methods. 1979; 25: 337-353
- Vitamine B12 regulates folate metabolism by the supply of formate.Lancet. 1980; II: 505-508
- The antimicrobial role of the neutrophil leukocyte.J Infect. 1981; 3: 3-17
- Effect of neonatal folic acid deprivation on late growth and susceptibility to Shigella infection in the guinea pig.Am J Clin Nutr. 1972; 25: 992-996
- Folate status and requirements in pregnancy.Br Med J. 1968; 2: 390-394
- Bactericidal activities of phagocytes in health and disease.Am J Clin Nutr. 1974; 27: 629-637
- Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency.Am J Clin Nutr. 1975; 28: 225-232
- Effect of vitamin B12 and folic acid deficiencies on neutrophil function.Blood. 1976; 47: 801-805
- Metabolic and bactericidal activities of leukocytes in protein-calorie malnutrition.Am J Clin Nutr. 1972; 25: 166-174
- Re-evaluation of nitroblue tetrazolium tests.Lancet. 1973; II: 879-893
- Neutrophil function in children with kwashiorkor.J Lab Clin Med. 1976; 88: 450-461
- Phagocytosis and leukocyte enzymes in protein-calorie malnutrition.Biochem J. 1972; 127: 255-259
- The folates.in: Barker BM Bender DA Vitamins in medicine. 4th ed. William Heinemann Medical Books, London1980: 247-314
Article info
Publication history
Accepted:
March 22,
1982
Footnotes
☆Dr. Youinou is supported by a fellowship from the Foundation de la Recherche Medicale.
Identification
Copyright
© 1982 Published by Elsevier Inc.
