Coronary risk factors and plasma sex hormones

      This paper is only available as a PDF. To read, Please Download here.


      Recent studies have reported higher plasma estradiol levels in male survivors of acute myocardial infarction. This finding has raised the possibility that hyperestrogenemia may constitute a separate coronary risk factor. In 443 men, aged 30,40,50, and 60, we assessed the relationship between plasma levels of estradiol, testosterone, and testosterone-binding globulin and coronary risk factors: fasting plasma concentrations of triglyceride, cholesterol, and high-density lipoprotein, blood pressure, and smoking and leisure-time physical activity patterns. Plasma estradiol concentrations were found to correlate significantly with body weight. After adjustment for this association, we found that the mean plasma estradiol concentration still was significantly higher in smokers than in nonsmokers. No other correlation could be established between plasma hormone levels and coronary risk factors. The relative hyperestrogenemia reported in men with previous myocardial infarction may be due to an effect of smoking but may also reflect the relationship between body weight and plasma estradiol levels. Future studies should consider the demonstrated association between plasma estrogen levels and smoking.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Veterans Administration Cooperative Urological Research Group
        Treatment and survival of patients with cancer of the prostate.
        Surg Gynecol Obstet. 1967; 124: 1011-1017
        • Coronary Drug Project Research Group
        The coronary drug project.
        JAMA. 1970; 214: 1303-1313
        • Phillips GB
        Evidence for hyperoestrogenaemia as a risk factor for myocardial infarction in man.
        Lancet. 1976; II: 14-18
        • Entrican JH
        • Beach C
        • Carroll D
        • et al.
        Raised plasma oestradiol and oestrone levels in young survivors of myocardial infarction.
        Lancet. 1978; II: 487-490
        • Levin LC
        • Korenman SG
        Elevated estradiol levels in acute Ml and coronary artery disease.
        Clin Res. 1978; 26: 308A
        • Phillips GB
        Sex hormones, risk factors and cardiovascular disease.
        Am J Med. 1978; 65: 7
        • Kostner GM
        Enzymatic determination of cholesterol in highdensity lipoprotein fractions prepared by polyanion precipitation.
        Clin Chem. 1976; 22: 695
        • Laurell S
        A method for the routine determination of plasma triglycerides.
        Scand J Clin Lab Invest. 1966; 18: 668-672
        • Grafnetter D
        • Fodor J
        • Teply V
        • Zacek K
        The effect of storage on levels of cholesterol in serum as measured by a simple direct method.
        Clin Chim Acta. 1967; 16: 33-37
        • Anderson DC
        • Lasley BL
        • Fisher RA
        • Shepherd JH
        • Newman L
        • Hendrick AG
        Transplacental gradients of sex-hormone-binding globulin in human and simian pregnancy.
        Clin Endocrinol. 1976; 5: 657-669
        • Nie NH
        • Hull CH
        • Jenkins JG
        • Steinbrenner K
        • Date HB
        Stratistical package for the social sciences.
        McGraw-Hill, New York1975
        • Overall JE
        • Spiegel DK
        Concerning least squares analysis of experimental data.
        Psychol Bull. 1969; 72: 311-322
        • Morris JN
        • Everitt MG
        • Pollard R
        • Chave SPW
        Vigorous exercise in leisure-time: protection against coronary heart disease.
        Lancet. 1980; II: 1207-1210