Advertisement

Reappearance of beriberi heart disease in Japan

A study of 23 cases
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Twenty-three Japanese patients with beriberi heart disease, 17 of them teenagers, were studied. The recent tendency for teenagers to take excessive sweet carbonated soft drinks, instant noodles and powermill-polished rice readily induces relative thiamine deficiency. A sudden increase in thiamine requirements due to strenuous exercise can result in overt beriberi heart disease. Alcohol had nothing to do with the development of the disease.
      Characteristic features commonly seen in teenage patients include peripheral edema, low peripheral vascular resistance, increased venous pressure, enlarged heart, T wave abnormalities, hyperkinetic circulatory state and increased circulating blood volume. Thiamine deficiency was confirmed by a decrease in blood thiamine concentration, a decrease in erythrocyte transketolase activity and an increase in thiamine pyrophosphate (TPP) effect. Improvement was rapidly achieved with thiamine administration, balanced nutrition and rest, especially in the teenage patients.
      Increased circulating blood volume was useful in differentiating beriberi heart disease from hyperthyroidism.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Inoue K
        • Katsura E
        Etiology and pathology of beriberi.
        in: Shimazono N Katsura E Review of Japanese literature on beriberi and thiamine. Vitamin B Research Committee of Japan. Igaku Shoin, Tokyo1975: 1
        • Shimazono J
        Kakke (beriberi) (in Japanese).
        Jap J Med. 1919; 7: 237
        • Shimazono J
        Beriberi.
        in: Stepp W Gyorgy P Avitaminosen und verwandte krankheitszustande. Julius Splinger, Berlin1927: 539
        • Abe T
        • Hashizume N
        • Igata A
        • et al.
        Studies on pathogenesis in beriberi heart disease and beriberi neuropathy (in Japanese).
        Nutrition Diet. 1977; 30: 523
        • Kawai C
        • Wakabayashi A
        • Hirose K
        • et al.
        A beriberi heartlike syndrome: metabolic heart disease or non-specific myocarditis (abstract)?.
        Jap Circ J. 1976; 40: 514
        • Kusukawa R
        • Kinoshita M
        • Shimono Y
        • et al.
        The clinical findings of seven cases with high output failure resembling beriberi syndrome (abstract).
        Jap Circ J. 1976; 40: 515
        • Seriu Y
        • Uehata H
        • Bito K
        • et al.
        Five young patients with beriberi heart disease (abstract).
        Jap Circ J. 1976; 40: 515
        • Yui Y
        • Fujiwara H
        • Mitsui H
        • et al.
        Furosemide-induced thiamine deficiency (abstract).
        Jap Circ J. 1978; 42: 744
        • Fujiwara M
        • Matsui K
        Determination of thiamine by the thiochrome reaction; application of cyanogen bromide in place of potassium ferricyanide.
        Anal Chem. 1953; 25: 810
        • Brin M
        • Tai M
        • Ostashever AS
        • et al.
        The effect of thiamine deficiency on the activity of erythrocyte hemolysate transketolase.
        J Nutr. 1960; 71: 273
        • Kuwahara M
        • Hirakawa A
        • Kinoshita M
        • et al.
        Analysis of radiocardiogram by analog computer simulation.
        Int J Biomed Eng. 1972; 1: 13
        • Remington RD
        • Schork MA
        Statistics with application to the biological and health sciences.
        in: Prentice-Hall, Englewood Cliffs, NJ1967: 192
        • Wolf PL
        • Levin MB
        Shoshin beriberi.
        N Engl J Med. 1960; 262: 1302
        • Toreson LWE
        Diffuse isolated myocarditis associated with dietary deficiency.
        Arch Intern Med. 1944; 73: 375
        • Yoshitoshi Y
        • Shibata N
        • Yamashita S
        Experimental studies on the beriberi heart. I. Cardiac lesions in thiamine deficient rats.
        Jap Heart J. 1961; 2: 42
        • Follis Jr, RH
        • Miller MH
        • Wintrobe MM
        • et al.
        Development of myocardial necrosis and absence of nerve degeneration in thiamine deficiency in pigs.
        Am J Pathol. 1943; 19: 341
        • Hirota Y
        • Kane RL
        • Abelmann WH
        Cardiovascular effects of exercise in hamsters with experimental thiamine deficiency.
        Jap Circ J. 1979; 43: 99