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Abstract
Vitamin D along with parathyroid hormone (PTH) and calcitonin (CT) are the three principal
effectors of calcium and phosphorus homeostasis. The secosteroid, vitamin D3, is subject to metabolic conversion to its biologically active form(s) 1,25-dihydroxyvitamin
D3 [1,25(OH)2D3] and 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] prior to initiation of its physiologic responses in the intestine and skeletal system.
The production of 1,25(OH)2D3 is stringently regulated by a variety of endocrine signals including PTH as well
as the “calcium needs” of the organism. At the target intestine, 1,25-(OH)2D3 stimulates the intestinal absorption of calcium via a mechanism analogous to that
of other steroid hormones. Definitive biochemical evidence exists supporting the existence
in the intestine of a highly specific protein receptor for 1,25(OH)2D3. After formation of the steroid-receptor complex, it migrates to the nucleus of the
cell and stimulates messenger-RNA synthesis for proteins (including a calcium-binding
protein) which are necessary for the generation of the biologic response. Current
efforts to biochemically characterize vitamin D-mediated intestinal calcium transport
include efforts to understand the role of calcium-binding protein in this process,
as well as to identify other protein components present either in the brush border
or basal lateral membranes.
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Article Info
Footnotes
☆This work was supported in part by USPHS Grants AM-09012 and AM-14750.
Identification
Copyright
© 1979 Published by Elsevier Inc. All rights reserved.
