Immune-complex glomerulonephritis in a patient with mixed connective tissue disease

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      Renal involvement and hypocomplementemia in mixed connective tissue disease are reported to be rare. A patient is described here with mixed connective tissue disease and persistently low serum C'3 levels in whom renal insufficiency and nephrotic syndrome developed secondary to immune-complex glomerulonephritis. Light microscopy of the renal biopsy specimen showed predominantly a membranous lesion. Immunofluorescent staining showed granular deposition along the basement membrane of immunoglobulin G, immunoglobulin M, fibrinogen and C3. Electron microscopy showed numerous electron-dense deposits along the glomerular capillary membrane and in the mesangium.
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        • Sharp GC
        • Irvin WS
        • Tan EM
        • et al.
        Mixed connective tissue disease. An apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA).
        Am J Med. 1972; 52: 148
        • Sharp GC
        • Irvin WS
        • LaRogue RL
        • et al.
        Association of au- 6. toantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy.
        J Clin Invest. 1971; 50: 350
        • Parker MD
        Ribonucleoprotein antibodies. Frequencies and clinical significance in systemic lupus erythematosus, scleroderma and mixed connective tissue disease.
        J Lab Clin Med. 1963; 82: 769
        • Sanders DY
        • Huntley CC
        • Sharp GC
        Mixed connective tissue disease in a child.
        J Pediatr. 1973; 83: 642
        • Sharp GC
        • Irvin WS
        • Northway JD
        • et al.
        Specificity of antibodies to extractable nuclear antigens (ENA) in mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE) (abstract).
        Arthritis Rheum. 1972; 15: 125
        • Tan EM
        • Northway JD
        • Pinnas JL
        The clinical significance of antinuclear antibodies.
        Postgrad Med. 1973; 54: 143
        • Venkateswara RK
        • Berkseth RO
        • Crosson JT
        • et al.
        Immune-complex nephritis in mixed connective tissue disease (letter).
        Ann Intern Med. 1976; 84: 174
      1. McDowell EM, Trump BF: Unpublished data.

        • Ehrenreich T
        • Churg J
        Pathology of membranous nephropathy.
        Pathol Annu. 1968; 3: 145
        • Morris AD
        • Littleton C
        • Corman LC
        • et al.
        Extractable nuclear antigen effect on the DNA anti-DNA reaction and NZB/NZW mouse nephritis.
        J Clin Invest. 1975; 55: 903