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Abstract
Lipid and lipoproiein values, including fasting triglycerides and high density lipoproteins
(HDL), low density llpoproteins (LDL) and total cholesterol levels, were obtained
on 2,815 men and women aged 49 to 82 years chiefly between 1969 and 1971 at Framingham.
In the approximately four years following the characterization of lipids, coronary
heart disease developed in 79 of the 1,025 men and 63 of the 1,445 women free of coronary
heart diseases. At these older ages the major potent lipid risk factor was HDL cholesterol,
which had an inverse association with the incidence of coronary heart disease (p <
0.001) in either men or women. This lipid was associated with each major manifestation
of coronary heart disease. These associations were equally significant even when other
lipids and other standard risk factors for coronary heart disease were taken into
consideration. A weaker association with the incidence of coronary heart disease (p
< 0.05) was observed for LDL cholesterol. Triglycerides were associated with the incidence
of coronary heart disease only in women and then only when the level of other lipids
was not taken into account. At these ages total cholesterol was not associated with
the risk of coronary heart disease.
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References
- Ischemic heart disease, atherosclerosis and longevity.Circulation. 1966; 34: 679
- Serum cholesterol lipoproteins, and risk of coronary heart diseases. The Framingham Study.Ann Intern Med. 1971; 24: 1
- Serum lipids, hypertension and coronary artery disease.Am J Med. 1961; 31: 4
- Ischemic heart disease in relation to fasting values of plasma triglycerides and cholesterol.Lancet. 1972; 1: 865
- Introduction and general background in the Framingham Study. The Framingham Study.National Heart and Lung Institute, Bethesda1968 (Sections 1 and 2)
- Some characteristics related to the incidence of cardiovascular disease and death. Framingham Study: 18-year follow-up.in: The Framingham Study. DHEW Publication (NIH) No. 74-599. U.S. Government Printing Office, Washington, D.C1974 (Section 30)
- Fat transport and lipoproteins—an integrated approach to mechanisms and disorders.N Engl J Med. 1967; 276: 32
- Fat transport and lipoproteins—an integrated approach to mechanisms and disorders.N Engl J Med. 1967; 276: 94
- Fat transport and lipoproteins—an integrated approach to mechanisms and disorders.N Engl J Med. 1967; 276: 148
- Fat transport and lipoproteins—an integrated approach to mechanisms and disorders.N Engl J Med. 1967; 276: 215
- Fat transport and lipoproteins—an integrated approach to mechanisms and disorders.N Engl J Med. 1967; 276: 273
Castelli WP, Cooper GR, Doyle JT, et al.: Distribution of triglyceride and total, LDL and HDL cholesterol in several populations: a cooperative lipoprotein phenotyping study. J Chronic Dis (in press).
- Sur un dosage rapide du cholesterol lie' aux α- et aux β-lipoproteins du serum.Clin Chim Acta. 1960; 5: 609
- A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity.J Biol Chem. 1952; 195: 357
- Fluorometric measurements of triglycerides.in: Skeggs Jr, LT Technicon Symposia Automation in Analytical Chemistry. Medicad Inc, New York1965: 341
- Estimation of the probability of an event as a function of several independent variables.Biometrika. 1967; 54: 167
- Quantitative and qualitative serum lipoprotein analysis. 2. Studies in male survivors of myocardial infarction.Atherosclerosis. 1975; 21: 435
Goldbourt Uri, Medalie JH: Cholesterol in alpha lipoprotein and clinical myocardial infarction. Submitted for publication.
- Plasma lipoprotein concentration in middle aged runners.Circulation. 1974; 50: 111
- Effect of exercise and physical fitness on serum lipids and lipoproteins.Atherosclerosis. 1974; 20: 1
- Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men.N Engl J Med. 1976; 294: 293
- Metabolic relationships among plasma lipoproteins, reciprocal changes in the concentrations of very low and low density lipoprotein in men.J Clin Invest. 1972; 51: 1051
- HDL cholesterol levels (HDLC) in coronary heart disease. A Cooperative Lipoprotein Phenotyping Study.Circulation. 1975; 52: II-97
- Longevity syndromes.Circulation. 1975; 52: II-272
- Protein-lipid relationships in human plasma.Am J Med. 1951; 11: 480
- Studies on the lipid-protein relationship in normal and pathologic sera and the effect of heparin or serum lipoproteins.Scand J Clin Lab Invest. 1953; 5 (suppl): 8
- Some chemical factors in the pathogenesis of atherosclerosis.Circulation. 1953; 8: 641
- Serum lipoprotein pattern in coronary sclerosis and associated conditions.Br Heart J. 1955; 17: 299
- A study of serum lipoproteins in normal and atherosclerotic patients by paper electropharetic techniques.J Clin Invest. 1956; 9: 980
- α-cholesterol percentages in coronary patients with and without increased total serum cholesterol levels and in healthy controls.J Atheroscler Res. 1962; 2: 424
- Influence of myocardial infarction on plasma lipoprotein concentration.Lancet. 1953; 1: 1160
- Serum cholesterol and relative body weight of coronary patients in different populations.Circulation. 1960; 22: 1031
- Recurring and fatal myocardial infarction in the Western Collaboration Group Study.Am J Cardiol. 1967; 19: 771
- Plasma-high-density-lipoprotein concentration and development of ischemic heart disease.Lancet. 1975; 1: 16
- Cholesterol turnover in men.Adv Lipid Res. 1970; 8: 1
- Physiological role of lecithin-cholesterol acyltransferase.Am J Clin Nutr. 1970; 23: 1129
- Lipid metabolism in cultured cells. 4. Serum alpha-globulin and cellular cholesterol exchange.Exp Cell Res. 1965; 37: 175
- Cholesterol excretion by tissue culture cells. Effect of serum lipids.Biochim Biophys Acta. 1969; 176: 616
- HDL dependent elimination of cholesterol from human arterial tissue.in: 3rd ed. Proc Eur Soc Clin Invest. 9. 1975: 51
- Familial lipoprotein deficiency (Tangier disease).in: Stanbury JS Wyngaarten JB Fredrickson DS The metabolic basis of inherited disease. 3rd ed. McGraw-Hill, New York1972: 513
- Effects of high density lipoprotein (HDL) on low density lipoprotein (LDL) metabolism by pig smooth muscle cells (SMC).Circulation. 1975; 52: II-273
Article info
Publication history
Accepted:
January 21,
1977
Identification
Copyright
© 1977 Published by Elsevier Inc.
