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The effect of hepatitis B on plasma cholesterol and sterol balance

  • Christopher D. Saudek
    Correspondence
    Requests for reprints should be addressed to Dr. Christopher D. Saudek, Room F-263, The New York Hospital-Cornell Medical Center, 1300 York Avenue, New York, New York 10021.
    Footnotes
    Affiliations
    New York, New York, USA
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  • Author Footnotes
    1 From The New York Hospital-Cornell University Medical College, Department of Medicine, Laboratory of Metabolism, New York, New York.
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      Abstract

      A patient with hepatitis B was studied by cholesterol balance technics throughout 29 days of the incubation period, the entire preicteric phase (49 days) and 15 days into the icteric phase. As hepatic inflammation developed, the plasma cholesterol concentration declined, reaching 56 per cent of its base line level before the onset of jaundice. Fecal bile acids diminished slightly whereas fecal neutral steroids were unchanged. As jaundice developed, the plasma cholesterol level rose abruptly and fecal bile acid excretion decreased markedly. This report suggests that plasma cholesterol is diminished by hepatitis prior to the development of icterus. Cholesterol synthesis is probably decreased.
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