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Abstract
The Ann Arbor Conference on the staging of Hodgkin's disease suggested that the prognosis
in patients with “E” stage Hodgkin's disease is similar to that in comparable patients
with only nodal disease. A comparative analysis was undertaken of 84 patients with
pathologically staged IIA to IIIA disease and 18 patients with stage IIEA to IIIEA disease. The lung was the principal site of extranodal extension (15 patients).
Both groups were treated concurrently with either extended field irradiation alone
or limited field irradiation followed by MOPP chemotherapy (nitrogen mustard, vincristine,
procarbazine and prednisone). Relapse rates after irradiation alone were 29 per cent
for the patients with stage HA to IIIA disease and 82 per cent for the patients with
“E” stage disease. Patients who received adjuvant chemotherapy had relapse rates of
6 per cent and 14 per cent, respectively. Most “E” stage relapses were regional recurrences
within the lung parenchyma. Wilcoxon analysis revealed a significantly shorter remission
duration and survival for the patients with “E” stage disease after irradiation alone,
but there were no differences between the two patient populations treated with irradiation
followed by chemotherapy. These data indicate that the prognosis in patients with
“E” stage Hodgkin's disease of the lung is poor when they are treated with irradiation
alone, and that adjuvant chemotherapy should be considered for such patients.
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Article Info
Publication History
Accepted:
December 30,
1976
Footnotes
☆This study was presented in part at the XVIIIth Annual Meeting of the American Society of Hematology, Dallas, Texas, December 6–9, 1975.
Identification
Copyright
© 1977 Published by Elsevier Inc.
