Medial calcinosis of Mönckeberg

A review of the problem and a description of a patient with involvement of peripheral, visceral and coronary arteries
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      Massive medial calcific deposits (Mönckeberg's calcinosis) are described in the peripheral and visceral arteries, and similar but small-sized deposits in the coronary arteries of a 41 year old woman with diabetes mellitus. Although observed by roentgenogram fairly commonly during life in the muscular arteries of the legs in middle-aged men, medial calcinosis infrequently involves the visceral arteries and has never, to our knowledge, been documented in the coronary arteries. Although it may be associated with intimai atherosclerosis, medial calcinosis, per se, does not obstruct the lumens of the arteries and, therefore, does not lead to symptoms or signs of limb or organ ischemia. The cause of medial calcinosis remains a mystery, but it appears to affect people with diabetes more frequently than those without.
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        • Mönckeberg JG
        Uber die Heine Mediaverkalkung der Extremitätenarterien and ihr Verhalten zur Arteriosklerose.
        Virchows Arch [Pathol Anat]. 1903; 171: 141
        • Mönckeberg JG
        Mediaverkalkung and Arteriosklerose.
        Virchows Arch [Pathol Anat]. 1914; 216: 408
        • Moschocowitz E
        Vascular Sclerosis.
        in: Oxford University Press, New York1942: 76
        • Silbert S
        • Lippmann HI
        Moenckeberg's sclerosis. A clinical entity.
        J Mt Sinai Hosp NY. 1945; 12–13: 689
        • Silbert S
        • Lippmann HI
        • Gordon E
        Mönckeberg's arteriosclerosis.
        JAMA. 1953; 151: 1176
        • Merlen JF
        Les calcinoses des membres inférieurs.
        Phlébologie. 1975; 28: 531
        • Cavaliero C
        • Martinazzi M
        • Turolla E
        • et al.
        Etudes morphologiques de la maladie arteriélle de Mönckeberg (calcification de la média). Revue de l'athérosclérose et des artériopathies périphériques.
        Arch Mal Coeur. 1968; 10: 2
        • Lindbom A
        Arteriosclerosis and arterial thrombosis in the lower limb; roentgenological study.
        Acta Radiol. 1950;
        • Donner MW
        • McAfee JG
        Roentgenographic manifestations of diabetes mellitus.
        Am J Med Sci. 1960; 239: 622
        • Ferrier TM
        Radiologically demonstrable arterial calcification in diabetes mellitus.
        Australas Ann Med. 1964; 13: 222
        • Mönckeberg JG
        Arterienverkalkung. Therapie d, Herzinsuffizienz.
        in: Georg Thieme Verlag, 1924: 63
        • Virchow R
        Mediaverkalkung and Arteriosklerose.
        Virchows Arch [Pathol Anat]. 1914; 216 (cit Mönckeberg JG:): 408
        • Klotz O
        Fracture of arteries.
        J Med Res. 1916; 34: 495
        • Jores L
        Arterien. Handbuch der Pathologischen. Anatomie. 1924; 2: 632
        • Hueck W
        Anatomisches zur Frage nach Wesen and Ursache der Arteriosklerose.
        Munch Med Wochenschr. 1920; 67: 535
        • Faber A
        Die Arteriosklerose.
        in: 1912: 81 (Jena)
        • Reinhardt K
        Nierenarterienverkalkung bei einer Diabetikerin mit Mönckeberg-Sklerose.
        Fortschr Geb Roentgenstr Nuklearmed. 1973; 119: 363
        • Seshanarayana KN
        • Keats TE
        Intrarenal arterial calcification: roentgen appearance and significance.
        Radiology. 1970; 95: 145
        • Moritz AR
        Arteriosclerosis of the abdominal vessels.
        (chap 16)in: Blumenthal HT Cowdry's Arteriosclerosis. Charles C Thomas, Springfield, Ill1967
        • Duguid JB
        Vitamin D sclerosis in the rat's aorta.
        J Pathol Bacteriol. 1930; 33: 697
        • Friedman WF
        • Roberts WC
        Vitamin D and the supravalvar aortic stenosis syndrome The transplacental effects of vitamin D on the aorta of the rabbit.
        Circulation. 1966; 34: 77
        • Erb W
        Experimentelle und Histologische studien über Arterienerkrankungen nach Adrenalininjektionen.
        Arch Exp Pathol Pharmakol. 1905; 53: 173
        • Cavallero C
        • Spagnoli LG
        • DiTondo U
        Early mitochondrial calcifications in the rabbit aorta after adrenalin.
        Virchows Arch [Pathol Anat Histol]. 1974; 362: 23
        • Bhagwat RR
        • Mittal S
        • Monga JN
        Medial calcification of intra-uterine arteries.
        J Indian Med Assoc. 1974; 63: 77
        • Moran JJ
        • Becker SM
        Idiopathic arterial calcification of infancy.
        Am J Clin Pathol. 1959; 31: 517
        • Christensen NJ
        Diabetic macroangiopathy: blood flow and radiological studies.
        Adv Metab Disord suppl. 1972; 2: 129