This paper is only available as a PDF. To read, Please Download here.
Abstract
Three weeks after a massive inhalation of mold present on infected oats, a farmer's
wife had extrinsic allergic alveolitis. Aspergillus fumigatus was cultured from the
moldy oats and from deep bronchial washings obtained at fiberoptic bronchoscopy. Spores
and hyphae characteristic of Aspergillus species were demonstrated within granulomas
in the pulmonary tissue obtained by transbronchial biopsy. Serum precipitins, delayed
(48 hour) cutaneous hypersensitivity and in vitro lymphocyte transformation to A.
fumigatus were demonstrated. The findings in this case suggest that a type IV immunologic
response and subsequent (lymphocyte-mediated) tissue inflammation may underlie the
pathogenesis of this and other forms of hypersensitivity pneumonitis.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The American Journal of MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Clinical Aspects of Immunology.in: F.A. Davis Co, Philadelphia1968: 575
- Bronchopulmonary aspergillosis: a review and a report of eight new cases.Thorax. 1952; 7: 317
- Allergic bronchopulmonary aspergillosis—a North American rarity: clinical and immunologic characteristics.Am J Med. 1969; 47: 306
- Hypersensitivity diseases of the lungs due to fungi and organic dusts.in: Monographs in Allergy. vol 4. S. Karger, Basel1969
- Farmer's lung following inhalation of Aspergillus flavus growing in mouldy corn.Clin Allergy. 1974; 4: 79
- Allergic alveolitis in a maltworker.Thorax. 1968; 23: 271
- Prevalence of respiratory symptoms and sensitization by mould antigens among a group of malt workers.Br J Industr Med. 1974; 31: 31
- Farmer's lung: an acute granulomatous interstitial pneumonitis occurring in agricultural workers.JAMA. 1958; 167: 1069
- Farmer's lung: clinical, pathologic and immunologic study of twenty-four patients.Am J Med. 1964; 37: 392
- Pneumonitis due to Cryptostroma corticale (maple bark disease).N Engl J Med. 1966; 274: 1413
- Pigeon-breeders' lung: a newly observed interstitial pulmonary disease.JAMA. 1965; 193: 261
- Bird breeder's (fancier's) lung.Lancet. 1966; 1: 445
- Pigeon breeders' disease: a clinical study of a hypersensitivity pneumonitis.Ann Intern Med. 1968; 68: 1205
- Bagassosis: a review with further historical data, studies of pulmonary function and results adrenal steroid therapy.Am J Med. 1958; 25: 234
- Bagassosis. I. Precipitins against extracts of crude bagasse in the serum of patients.Ann Intern Med. 1966; 64: 748
- Avian-induced hypersensitivity pneumonitis.Can Med Assoc J. 1972; 107: 1196
- Immunology of the lower respiratory tract.Clin Allergy. 1973; 3 (suppl): 653
- The pathology of acute and chronic stages of farmer's lung.Thorax. 1968; 23: 469
- Allergic bronchopulmonary aspergillosis: clinical and pathological study of three cases.Chest. 1971; 59: 33
- Immunofluorescent studies in patients with farmer's lung.J Allergy Clin Immunol. 1971; 48: 224
- Immunologic mechanisms in hypersensitivity pneumonitis. I. Evidence for cell-mediated immunity and complement fixation in pigeon breeder's disease.J Allergy Clin Immunol. 1973; 52: 225
- Pigeon breeder's disease: study of the cell-mediated immune response to pigeon antigens by the lymphocyte culture technique.Int Arch Allergy Appl Immunol. 1974; 47: 498
- Immunologic events in pigeon breeder's disease.J Allergy Clin Immunol. 1974; 53: 319
- Experimental production of hypersensitivity pneumonitis with bagasse and thermophilic actinomycete antigen.J Allergy Clin Immunol. 1972; 50: 276
- Acute experimental hypersensitivity pneumonitis in rabbits.Am Rev Respir Dis. 1971; 104: 568
- Measurement of IgE in normal and allergic serum by radioimmunoassay.J Lab Clin Med. 1971; 77: 690
- Diagnostic mycoserology by immunoelectro-osmophoresis.Am J Clin Pathol. 1971; 57: 471
- Counterelectrophoresis as a rapid method for the detection of aspergillus precipitins in pulmonary disease.Chest. 1973; 63 (suppl): 49
- Use of the immunodiffusion test in the serodiagnosis of aspergillosis.Appl Microbiol. 1972; 23: 301
- Immunological responsiveness of frozen-thawed human lymphocytes.Clin Exp Immunol. 1975; 21: 442
- Serum immunoglobulin levels in pulmonary allergic aspergillosis and certain other lung diseases, with special reference to immunoglobulin E.Am J Med. 1973; 54: 16
- Serum immunoglobulin levels in farmer's lung disease.J Allergy Clin Immunol. 1973; 52: 297
- Allergic bronchopulmonary aspergillosis: evidence of limited tissue invasion.Rev Respir Dis. 1975; 111: 232
- Lung biopsies of pigeon breeders' disease.Arch Pathol. 1969; 87: 572
- Interstitial pneumonitis due to hypersensitivity to an organism contaminating a heating system.Ann Intern Med. 1971; 74: 80
- Hypersensitivity pneumonitis related to a home furnace humidifier.J Allergy Clin Immunol. 1971; 48: 171
Article Info
Publication History
Accepted:
January 23,
1976
Footnotes
☆This work was supported by the U.S. Navy Bureau of Medicine and Surgery, Clinical Investigation Program CICC No. 4-06-305 and CICC No. 4-06-381. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy or the Department of Defense.
Identification
Copyright
© 1976 Published by Elsevier Inc.
