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Abstract
Three weeks after a massive inhalation of mold present on infected oats, a farmer's
wife had extrinsic allergic alveolitis. Aspergillus fumigatus was cultured from the
moldy oats and from deep bronchial washings obtained at fiberoptic bronchoscopy. Spores
and hyphae characteristic of Aspergillus species were demonstrated within granulomas
in the pulmonary tissue obtained by transbronchial biopsy. Serum precipitins, delayed
(48 hour) cutaneous hypersensitivity and in vitro lymphocyte transformation to A.
fumigatus were demonstrated. The findings in this case suggest that a type IV immunologic
response and subsequent (lymphocyte-mediated) tissue inflammation may underlie the
pathogenesis of this and other forms of hypersensitivity pneumonitis.
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Article Info
Publication History
Accepted:
January 23,
1976
Footnotes
☆This work was supported by the U.S. Navy Bureau of Medicine and Surgery, Clinical Investigation Program CICC No. 4-06-305 and CICC No. 4-06-381. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Navy or the Department of Defense.
Identification
Copyright
© 1976 Published by Elsevier Inc.