Pituitary gigantism

Endocrine studies in a subject with hypergonadotropic hypogonadism
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      Pituitary gigantism in a forty-nine year old man first became obvious at age eleven years. Between ages eighteen and twenty-one years growth ceased spontaneously, leaving him 93 inches tall and weighing 300 pounds. He had an enlarged sella turcica and features of acromegaly. He also had gynecomastia and hypergonadotropic hypogonadism. His buccal smear was sexchromatin negative but a culture of testicular tissues showed XY/XXY mosaicism. His level of plasma growth hormone was low, even during insulin-induced hypoglycemia. No other endocrine abnormality could be detected, and in particular, thyroid function and the hypothalamic-pituitary-adrenal axis were normal. His major disability resulted from deformities of both feet with infection and eventual amputation of both legs.
      We presume that he experienced spontaneous remission of hypersomatotropism without the development of other abnormalities of pituitary function. The roles of increased gonadotropin secretion, infection or two treatments by a radiotherapist are entirely speculative.
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