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Oliguric renal failure in blackwater fever

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      Abstract

      Blackwater fever is recurring in Central Africa and African subjects are now being affected. One Caucasian and five African patients are described in whom massive haemolysis due to malaria was followed by acute renal failure with oliguria lasting between twelve and thirty-three days. Renal biopsy showed evidence of tubular damage, but no obstruction with blood pigment, in each case. Drug therapy and deficiency of glucose-6-phosphate dehydrogenase were shown not to be essential in the production of haemolysis. The efficacy of treatment of the renal failure by early and repeated dialysis was confirmed, and five of the six patients recovered.
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