Oliguric renal failure in blackwater fever

      This paper is only available as a PDF. To read, Please Download here.


      Blackwater fever is recurring in Central Africa and African subjects are now being affected. One Caucasian and five African patients are described in whom massive haemolysis due to malaria was followed by acute renal failure with oliguria lasting between twelve and thirty-three days. Renal biopsy showed evidence of tubular damage, but no obstruction with blood pigment, in each case. Drug therapy and deficiency of glucose-6-phosphate dehydrogenase were shown not to be essential in the production of haemolysis. The efficacy of treatment of the renal failure by early and repeated dialysis was confirmed, and five of the six patients recovered.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Ross G.R.
        Blackwater fever in Southern Rhodesia in retrospect.
        Central African J. Med. 1962; 8: 294
      1. Weinberg, R. W. Personal communication, 1967.

        • Pearse A.G.E.
        2nd. ed. J. & A. Churchill, Ltd, London1961
        • Gilles H.M.
        • Taylor B.G.
        The existence of the glucose-6-phosphate dehydrogenase deficiency trait in Nigeria and its clinical implications.
        Ann. Trop. Med. 1961; 55: 64
        • Clark P.B.
        • Parsons F.M.
        Routine use of the Scribner shunt for haemodialysis.
        Brit. M. J. 1966; 1: 1200
        • Ross G.R.
        Studies on malaria and blackwater fever in Southern Rhodesia.
        Mem. Lond. School Hyg. & Trop. Med. 1932;
      2. Gelfand, M. Personal communication, 1967.

        • Findlay G.M.
        • Markson J.L.
        Attempts to induce blackwater fever experimentally.
        Ann. Trop. Med. 1947; 41: 22
        • Maegraith B.G.
        Pathological Processes in Malaria and Blackwater Fever.
        Blackwell Scientific Publications, Oxford1948
        • Adams A.R.D.
        • Maegraith B.G.
        Clinical Tropical Diseases.
        3rd ed. Blackwell Scientific Publications, Oxford1964
        • Stephens J.W.W.
        • Stott W.
        Studies in blackwater fever. III. The relationship of quinine to blackwater fever.
        Ann. Trop. Med. 1915; 9: 201
        • Browne S.G.
        A fatal case of blackwater fever associated with ingestion of nivaquine.
        Tr. Roy. Soc. Trop. Med. & Hyg. 1954; 48: 250
        • Molenaar J.C.
        • Voors A.W.
        Blackwater fever after the use of chloroquine (pyrimethamine).
        Trop. Geogr. Med. 1963; 15: 219
        • Gilles H.M.
        • Ikeme A.C.
        Haemoglobinuria among adult Nigerians due to glucose-6-phosphate dehydrogenase deficiency with drug sensitivity.
        Lancet. 1960; 2: 889
        • Russell P.F.
        • West L.S.
        • Manwell R.D.
        • MacDonald G.
        Practical Malariology.
        2nd ed. Oxford University Press, Oxford1963
        • Carson P.E.
        • Frischer H.
        Glucose-6-phosphate dehydrogenase deficiency and related disorders of the pentose phosphate pathway.
        Am. J. Med. 1966; 41: 744
        • Maegraith B.G.
        Blackwater fever anuria.
        Tr. Roy. Soc. Trop. Med. & Hyg. 1944; 38: 1
        • Jackson R.C.
        • Woodruff A.W.
        The artificial kidney in malaria and blackwater fever.
        Brit. M. J. 1962; 1: 1367
        • Dukes D.C.
        • MacDougall B.R.D.
        • Ornegliemann R.H.
        • Davidson L.
        Urinary leucocyte excretion in African subjects; its relation to the output of bilharzial ova.
        Brit. M. J. 1967; 1: 537
        • Yorke W.
        • Nauss R.W.
        The mechanism of the production of suppression of urine in blackwater fever.
        Ann. Trop. Med. 1911; 5: 287
        • Harrison H.E.
        • Bunting H.
        • Ordway N.K.
        • Albrink W.S.
        The pathogenesis of the renal injury produced in the dog by haemoglobin or methaemoglobin.
        J. Exper. Med. 1947; 86: 339
        • Lalich J.J.
        The influence of available fluid on the production of experimental hemoglobinuric nephrosis in rabbits.
        J. Exper. Med. 1948; 87: 157
        • Sitprija V.
        • Indraprasit S.
        • Pochanugool G.
        • Benyajati C.
        • Piyaratn P.
        Renal function in malaria.
        J. Trop. Med. & Hyg. 1966; 69: 242
        • Sitprija V.
        • Indraprasit S.
        • Pochanugool G.
        • Benyajati C.
        • Piyaratn P.
        Renal failure in malaria.
        Lancet. 1967; 1: 185
        • Reid H.A.
        • Goldsmith H.J.
        • Wright F.H.
        Peritoneal dialysis in acute renal failure following malaria.
        Lancet. 1967; 2: 436