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Clinical study| Volume 45, ISSUE 6, P880-888, December 01, 1968

Postural hypoxemia and erythrocytosis

DOI:https://doi.org/10.1016/0002-9343(68)90186-1
Postural hypoxemia and erythrocytosis
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      Abstract

      Seven patients with unexplained erythrocytosis, moderate obesity, and mild hypertension without splenomegaly (Gaisböck's syndrome) were studied. Routine pulmonary studies were normal, but significant arterial hypoxemia was demonstrated in the supine position in all patients. An increase in the serum level of erythropoietin in the supine position was found in five of six patients. Nocturnal oxygen therapy controlled the erythrocytosis in one patient and weight reduction was effective in controlling the hematocrit in another. We were unable to confirm the existence of “Gaisböck's syndrome.” The importance of a complete pulmonary evaluation, including arterial blood gas analysis in the supine position, in all patients with an unexplained erythrocytosis is emphasized. The finding of significant hypoxemia in the supine position in all patients in this study suggests that postural hypoxemia may be a frequent cause of an elevated red cell volume.
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      References

        • Lawrence J.H.
        • Berlin N.I.
        Relative polycythemia—the polycythemia of stress.
        Yale J. Biol. & Med. 1952; 24: 498
        • Russell R.P.
        • Conley C.L.
        Benign polycythemia: Gaisbock's syndrome.
        Arch. Int. Med. 1964; 114: 734
        • Hall C.A.
        Gaisbock's disease: redefinition of an old syndrome.
        Arch. Int. Med. 1965; 116: 4
        • Gaisbock F.
        Die Bedeutung der Blutdruckmessung für die ärztliche Praxis.
        Deutsche Arch. klin. Med. 1905; 83: 363
        • Murray J.F.
        Arterial studies in primary and secondary polycythemic disorders.
        Am. Rev. Resp. Dis. 1965; 92: 435
        • Trask C.H.
        • Cree E.M.
        Oximeter studies on patients with chronic obstructive emphysema, awake and during sleep.
        New England J. Med. 1962; 266: 639
        • Fishman A.P.
        • Turino G.M.
        • Bergofsky E.H.
        The syndrome of alveolar hypoventilation.
        Am. J. Med. 1957; 23: 333
        • Fried W.
        • Plzak L.E.
        • Jacobson L.D.
        • Goldwasser E.
        Studies on erythropoiesis. III. Factors controlling erythropoietin production.
        in: 2nd. ed. Proc. Soc. Exper. Biol. & Med.94. 1957: 237
        • Ward H.P.
        An in vitro assay of erythropoietin.
        in: 2nd. ed. Proc. Soc. Exper. Biol. & Med.125. 1967: 370
        • Block M.
        • Bethard W.F.
        Bone marrow studies in polycythemia.
        J. Clin. Invest. 1952; 31: 618
        • Sterling K.
        • Gray S.J.
        Circulatory red cell volume in man by radioactive chromium.
        J. Clin. Invest. 1950; 29: 1614
        • Storaasli J.P.
        • Krieger H.
        • Friedell H.L.
        • Holden W.P.
        Use of radioactive iodinate plasma protein in study of blood volume.
        Surg. Gynec. & Obst. 1950; 91: 458
        • Chaplin Jr., H.
        • Mollison P.L.
        • Vetter H.
        The body venous hematocrit ratio: its constancy over a wide hematocrit range.
        J. Clin. Invest. 1953; 32: 1309
        • Ward H.P.
        The effect of chloramphenicol on RNA and heme synthesis in bone marrow cultures.
        J. Lab. & Clin. Med. 1966; 68: 400
        • Dubois A.B.
        • Botelho S.Y.
        • Bedel G.N.
        • Marshall R.
        • Comroe J.H.
        A rapid plethysmographic method for measuring thoracic gas volumes: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects.
        J. Clin. Invest. 1956; 35: 322
        • Filley G.F.
        • MacIntosh D.J.
        • Wright G.W.
        Carbon monoxide uptake and pulmonary diffusing capacity in normal subjects at rest and during exercise.
        J. Clin. Invest. 1954; 33: 530
        • Severinghaus J.W.
        • Bradley A.F.
        Electrodes for blood Po2 and Pco2 determinations.
        J. Appl. Physiol. 1958; 13: 515
        • Astrup P.
        • Siggard-Anderson O.
        • Jorgensen K.
        • Engle K.
        The acid base metabolism: a new approach.
        Lancet. 1960; 1: 1035
        • Severinghaus J.W.
        Blood gas calculator.
        J. Appl. Physiol. 1966; 21: 1108
        • Pierce A.K.
        • Jarrett C.E.
        • Werkle Jr., G.
        • Miller W.F.
        Respiratory function during sleep in patients with chronic obstructive lung disease.
        J. Clin. Invest. 1966; 45: 631
        • Lange R.D.
        • Pavlovic-Kentera V.
        Erythro poietin.
        in: 2nd. ed. Progress in Hematology. vol. 4. Grune & Stratton, Inc, New York1964: 72
        • Van Dyke D.
        • Pollycove M.
        The relation of erythropoietin to anemia and polycythemia.
        in: Jacobson L.O. Doyle M. Erythropoiesis. Grune & Stratton, Inc, New York1962: 340
        • Birchfield R.I.
        • Sieker H.O.
        • Heyman A.
        Alterations in respiratory function during natural sleep.
        J. Lab. & Clin. Med. 1959; 54: 216
        • Ward R.J.
        • Tolass A.G.
        • Beniste R.J.
        • Hansen J.M.
        • Bonieu J.J.
        Effect of posture on normal arterial gas tensions in the aged.
        Geriatrics. 1966; 21: 139
        • Bigelow D.B.
        • Petty T.L.
        • Levine B.E.
        • Filley G.F.
        • Finigan M.M.
        The effect of oxygen breathing on arterial blood gases in patients with chronic airway obstruction living at 5,200 feet.
        Am. Rev. Resp. Dis. 1967; 96: 28

      Article Info

      Publication History

      Received: December 19, 1967

      Footnotes

      ☆This study was supported by Grant FR-0051 U.S. Public Health Service, Washington D.C., and Veterans Administration Research Funds.

      Identification

      DOI: https://doi.org/10.1016/0002-9343(68)90186-1

      Copyright

      © 1968 Published by Elsevier Inc.

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