Submicroscopic alterations in capillaries of skeletal muscles in polymyositis

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      Electron microscopic changes in capillaries of muscle are described in four patients with polymyositis. Marked thickening and lamination of basement membrane and various degrees of endothelial swelling, to the point of causing obstruction of the lumen, were found when compared to control subjects.
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        • Pearson C.M.
        • Rose A.S.
        Myositis. The inflammatory disorders of muscle. Neuromuscular disorders.
        Res. Publ. A. Nerv. & Ment. Dis. 1961; 38: 422
        • Adams R.D.
        • Denny-Brown D.
        • Pearson C.M.
        Diseases of Muscle. A Study in Pathology.
        2nd ed. Paul B. Hoeber, Inc, New York1962
        • Pearson C.L.
        Polymyositis and dermatomyositis.
        in: Samter M. Immunological Diseases. Little, Brown & Co, Boston1965
        • Banker B.Q.
        • Victor M.
        Dermatomyositis (systemic angiopathy) of childhood.
        Medicine. 1966; 45: 261
        • Mintz G.
        • González-Angulo A.
        • Fraga A.
        • Zavala B.J.
        The ultrastructure of muscle in polymyositis.
        Am. J. Med. 1968; 44: 216
        • Palade G.E.
        A study of fixation for electron microscopy.
        J. Exper. Med. 1952; 195: 285
        • Mollenhauer H.H.
        Plastic embedding mixtures for use in electron microscopy.
        Stain Technol. 1964; 39: 111
        • Watson M.L.
        Staining of tissue sections for electron microscopy with heavy metals.
        J. Biophys & Biochem. Cytol. 1958; 4: 475
        • Reynolds E.S.
        The use of lead citrate at high pH as an electron opaque stain in electron microscopy.
        J. Cell Biol. 1963; 17: 208
        • Martin J.H.
        • Lynn J.A.
        • Nickey W.M.
        A rapid polychrome stain for epoxy-embedded tissue.
        Am. J. Clin. Path. 1966; 46: 250
        • Bennet H.S.
        • Luft J.H.
        • Hampton J.C.
        Morphological classification of vertebrate blood capillaries.
        Am. J. Physiol. 1959; 196: 381
        • Palade J.E.
        Fine structure of blood capillaries.
        J. Appl. Physiol. 1953; 24: 1424
        • Palade G.E.
        Blood capillaries of the heart and other organs.
        Circulation. 1961; 24: 368
        • Fernando N.V.P.
        • Movat H.Z.
        The fine structure of the terminal vascular bed. III. The capillaries.
        Exper. & Molec. Path. 1964; 3: 87
        • Boehme D.
        • Themann H.
        • Gold J
        Structural and ultrastructural changes in striated human muscle caused by chronic ischemia.
        Am. J. Path. 1966; 49: 569
        • Zacks S.I.
        • Pegues J.J.
        • Elliott F.A.
        Interstitial muscle capillaries in patients with diabetes mellitus: a light and electron microscope study.
        Metabolism. 1962; 11: 381
        • Bencosme S.A.
        • West R.O.
        • Kerr J.W.
        • Wilson D.L.
        Diabetic capillary angiopathy in human skeletal muscles.
        Am. J. Med. 1966; 40: 67
        • Pardo V.
        • Perez-Stable E.
        • Fisher E.R.
        Electron microscopic study of dermal capillaries in diabetes mellitus.
        Lab. Invest. 1966; 15: 1994
        • Lames R.A.
        • Lange L.S.
        Clinical and pathological study of ischaemic neuropathy.
        J. Neurol. Neurosurg. & Psychiat. 1967; 30: 215
        • Donahue S.
        • Zeman W.
        • Watanabe I.
        Alterations of basement membranes of cerebral capillaries.
        J. Neuropath. & Exper. Neurol. 1967; 26: 397
        • Lindsey J.R.
        • Hopkins I.J.
        • Clark D.B.
        Pathology of nemaline myopathy. Studies of two adult cases including an autopsy.
        Bull. Johns Hopkins Hosp. 1966; 119: 378
        • Stehbens W.E.
        Ultrastructure of vascular endothelium in the frog.
        Quart. J. Exper. Physiol. 1965; 50: 375
        • Stehbens W.E.
        • Silver M.D.
        Unusual development of basement membrane about small blood vessels.
        J. Cell. Biol. 1965; 26: 669
        • Norton W.L.
        • Hurd E.
        • Lewis D.
        • Ziff M.
        Peripheral microvascular injury in scleroderma and systemic lupus erythematosus.
        in: Panamerican Congress of Rheumatology. 2nd. ed. Excerpta Médica International Congress Series No. 143. 1967: 154 (Abstract No. 103) México, D.F.