Advertisement

A familial study of procainamide-induced systemic lupus erythematosus

A question of pharmacogenetic polymorphism
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      The family of a person in whom a lupus-like syndrome developed following the administration of procainamide was studied by detailed medical histories, hematologic, serologic and coagulation means. Of the ten members of the family available for study, five had significant histories and/or laboratory findings suggestive of an immunologic disorder. Serum from three members demonstrated the presence of antinuclear antibody. Coagulation abnormalities were found in three others. Pertinent reports from the literature are discussed and this information is correlated with current etiologic concepts to advance the hypothesis that drug induced systemic lupus erythematosus may be an expression of pharmacogenetic polymorphism.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to The American Journal of Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Ladd A.T.
        Procaine amide-induced lupus erythematosus.
        New England J. Med. 1962; 267: 1357
        • Hargraves M.M.
        • Richmond H.
        • Morton R.
        Presentation of two bone marrow elements: the “tart” cell and the L.E. cell.
        in: 2nd ed. Proc. Staff Meet. Mayo Clin.23. 1948: 25
        • Dubois L.
        • Freeman V.
        A comparative evaluation of the L.E. cell test performed simultaneously by different methods.
        Blood. 1957; 12: 657
        • Friou G.J.
        Fluorescent spot test for antinuclear antibodies.
        Arthritis & Rheumat. 1962; 5: 407
        • Hahn A.L.
        Systemic lupus erythematosus associated with procaine amide therapy.
        Missouri Med. 1964; 61: 19
        • Kaplan J.M.
        • Wachtel H.L.
        • Czarneck S.W.
        • Sampson J.J.
        Lupus-like illness precipitated by procaine amide hydrochloride.
        J.A.M.A. 1965; 192: 444
        • Compton-Smith R.N.
        • Fawcett J.W.
        Systemic lupus erythematosus associated with procainamide.
        Brit. J. Clin. Pract. 1967; 21: 248
        • Carabia A.G.
        Case report: lupus-like syndrome with positive Hargraves phenomenon induced by pronestyl therapy; analysis of the test.
        J. Tennessee M. A. 1965; 58: 287
        • Colman R.W.
        • Sturgill B.C.
        Lupus-like syndrome induced by procaine amide.
        Arch. Int. Med. 1965; 115: 214
        • Paine R.
        Procaine amide hydrochloride and lupus erythematosus.
        J.A.M.A. 1965; 194: 23
        • Procnop L.D.
        Myotonia, procaine amide and lupus-like syndrome.
        Arch. Neurol. & Psychiat. 1966; 14: 326
        • London B.L.
        • Lincus I.
        Reversible lupus-like illness induced by procainamide.
        Am. Heart J. 1966; 72: 806
        • Hanlon T.M.
        • Binkiewicz A.
        • Feingold M.
        • Necheles T.F.
        Procainamide HCl-induced lupus syndrome in a child with myotonia congenita.
        Am. J. Dis. Child. 1967; 113: 491
        • Fakhro A.M.
        • Ritchie R.F.
        • Lown B.
        Lupus-like syndrome induced by procainamide.
        Am. J. Cardiol. 1967; 20: 367
        • McDevitt D.G.
        • Glascow J.F.T.
        Lupus-like syndrome induced by procainamide.
        Brit. M. J. 1967; 3: 780
        • Alarcon-Segovia D.
        • Wakim K.G.
        • Worthington J.W.
        • Ward L.E.
        Clinical and experimental studies on the hydralazine syndrome and its relationship to systemic lupus erythematosus.
        Medicine. 1967; 46: 1
      1. National Diseases and Therapeutic Index. 1966; 5: 2250
        • Evans D.P.
        Conjoint clinic on drugs and genes.
        J. Chron. Dis. 1965; 18: 59
      2. MacDonald, G. E. R. Squibb & Sons personal communication.

        • Hellman E.
        Allergy to procaine amide.
        J.A.M.A. 1952; 149: 1393
        • Pollak V.E.
        Antinuclear antibodies in families of patients with systemic lupus erythematosus.
        New England J. Med. 1964; 271: 165
        • Ziff M.
        Genetics, hypersensitivity and connective tissue diseases.
        Am. J. Med. 1961; 30: 1
        • Brunjes S.
        • Zike K.
        • Julian R.
        Familial systemic lupus erythematosus.
        Am. J. Med. 1961; 30: 529
        • Lee S.L.
        • Rivero I.
        • Siegal M.
        Activation of systemic lupus erythematosus by drugs.
        Arch. Int. Med. 1966; 117: 620