Pituitary function in haemochromatosis

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      Pituitary failure is not uncommon in haemochromatosis. Four of fifteen patients investigated had severe pituitary deficiency by both clinical and laboratory criteria and five had evidence of a partial defect, with failure of at least one trophic hormone. The pituitary failure appears to be due to iron deposition in the anterior pituitary and is not related to the severity of liver disease or to the degree of abnormality of either iron or oestrogen metabolism. Recognition and treatment of this complication is important in the management of haemochromatosis.
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