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A Unique lymphoproliferative disorder associated with an IgM platelet agglutinin, diffuse hypergammaglobulinemia, amyloid deposition and excessive urinary excretion of IgG fragments

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      Abstract

      A case is reported of a lymphoproliferative disorder with autoimmune hemolytic anemia and thrombocytopenia. Platelet agglutinins were demonstrated to be 19S gamma macroglobulins, a unique observation. The disease was initially manifested by lymphocyte and reticulum cell proliferation, and eventually by plasma cell proliferation with amyloid deposition. The patient's serum exhibited extreme diffuse hypergammaglobulinemia with an increase in both IgG and IgM components. The urine was remarkable for its high content of kappa and lambda light chains, Fd-like fragments and Fc-like fragments. The interrelationships between the pathologic findings and protein abnormalities are briefly discussed and compared with the lymphoma associated dysproteinemias reported in the literature.
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