This paper is only available as a PDF. To read, Please Download here.
Abstract
This is a review of the eight deaths from plague in the United States during the last
decade. Three cases not previously reported are described and tissue specimens in
four of the remaining five were available for examination. In four cases, all in children,
fibrin thrombi were present in glomerular capillaries and elsewhere. This finding
is the major pathologic manifestation of disseminated intravascular coagulation, which
may be responsible for the hemorrhagic phenomena in plague because of the consumption
of clotting factors. The similarity of the lesions to those of the generalized Shwartzman
phenomenon suggests that lipopolysaccharide endotoxins of Pasteurella pestis may be
responsible for the toxicity of this infection, and especially for the deaths in the
patients whose tissues had been successfully sterilized by antibiotics.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to The American Journal of MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Plague in 1965.Weekly Epidemiological Record. 1966; 41: 362
- Chloramphenicol and terramycin in the treatment of pneumonic plague.Am. J. Med. 1953; 14: 284
- Plague.in: Harrison T.R. Adams R.D. Bennett Jr., I.L. Resnick W.H. Thorn G.W. Wintrobe M.M. Principles of Internal Medicine. 5th ed. Blakiston Co, New York1966: 1573
- Studies on the pathogenesis of plague. Blood coagulation and tissue responses of Macaca mulatta following exposure to aerosols of Pasteurella pestis.Am. J. Path. 1968; 53: 99
- Disseminated Intravascular Coagulation.in: Paul B. Hoeber, Inc, New York1965: 493
- The local and generalized Shwartzman phenomena.in: Zweifach B.W. Grant L. McCluskey R.T. The Inflammatory Process. Academic Press, Inc, New York1965: 791
- Plague.in: World Health Organization, Geneva1954: 121
- Mechanisms of antibiotic action.Ann. Rev. Microbiol. 1965; 19: 209
Gustin, S. T. Manuscript in preparation.
- Beitrag zur pathologischen Anatomie der Pest.Schweiz. Ztschr. allg. Path. 1957; 20: 47
- Plague.New England J. Med. 1962; 267: 543
Caten, J. L. Personal communication, 1967.
- The Plague: Bacteriology, Morbid Anatomy, and Histopathology.in: Bureau of Public Printing, Manila1904: 127
- Studies on pneumonic plague and plague immunization.Philippine J. Sc. 1912; 7: 203
- Pathologic anatomy of bubonic plague.Philippine J. Sc. 1915; 10: 249
- Notes on the histology of some of the lesions found in pneumonic plague.in: Manchurian Plague Prevention Service Memorial. vol. 1912–1932. National Quarantine Service, Shanghai1934: 21
- Plague pathology and bacteriology.in: Proceedings of the Conference of State and Provincial Health Authorities of North America. 1926: 68
- A review of recent literature on plague.Bull. World Health Organ. 1960; 23: 313
- Plague.Ann. Rev. Microbiol. 1955; 9: 253
- A specific polysaccharide of Pasteurella pestis.Biochem. J. 1956; 63: 105
- Composition of and pathophysiology produced by plague endotoxins.Nature. 1966; 209: 1246
- Clinical and genetic aspects of coagulopathies, with special emphasis on generalized intravascular clotting.Ann. Int. Med. 1965; 62: 744
Article info
Publication history
Received:
September 26,
1967
Identification
Copyright
© 1968 Published by Elsevier Inc.
