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The relationship of serum uric acid to risk factors in coronary heart disease

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      Abstract

      Analysis of the uric acid data from the initial examination cycle of the Tecumseh Community Health Study reveals that not only age and sex but also body weight or build should be considered when evaluating serum uric acid levels in disease or relating serum uric acid levels to other physiologic variables. It was found that serum uric acid levels of persons with coronary heart disease were not significantly different from the mean of the population studied and hence cannot be considered an attribute associated with the disease. Furthermore, there appears to be no evident relationship between serum uric acid levels and serum cholesterol or blood sugar, both of which are regarded as risk factors for coronary heart disease. Although there is no consistent pattern of a relationship between uric acid levels and casual blood pressure levels, some trends are suggestive. Of the conditions and disease states studied, only gout and pregnancy differed significantly from the means of the entire population with respect to serum uric acid scores; the levels in gouty subjects, as expected, were higher and in pregnant women lower, confirming reports in the literature.
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