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A study was made of eight very obese patients, average body weight 325 pounds, with the alveolar hypoventilation syndrome. Initial treatment included a low calorie intake, the administration of digitalis and diuretics, and intermittent positive pressure breathing. After a stable level of improvement was reached, within five to twenty-three days, 100 mg. of progesterone was given daily by intramuscular injection. Progesterone therapy increased alveolar ventilation by an additional 29.3 per cent and total minute ventilation by 20.6 per cent. Arterial blood gas tensions and pH were returned toward normal and respiratory acidosis was abolished. Abnormal ventilatory-carbon dioxide response curves were restored to normal by progesterone therapy. Progesterone is thus an effective agent for improving ventilation in patients with the obesity-hypoventilation syndrome. The site and mode of action of progesterone is unknown. Respiratory control was normal during progesterone administration, but reappearance of an abnormal state recurred within a month after progesterone therapy was discontinued.
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- Ein Beitrag zur Respirationphysiologie der Graviditaet.Skandinav. Arch. Physiol. 1912; 27: 1
- Ueber die Kohlensäurespannung des Blutes in der Graviditaet.Ztschr. klin. Med. 1912; 75: 301
- Die Neutralitaetregulation des graviden Organismus.Biochem. Ztschr. 1915; 68: 206
- Atmung und Saeure-Basengleichgewicht in der Schwangerschaft.Arch. ges. physiol. 1947; 249: 437
- Alveolar carbon dioxide tension levels during pregnancy and early puerperium.J. Clin. Endocrinol. 1954; 14: 522
- Respiratory and acid-base changes during pregnancy.Anesthesiology. 1965; 26: 381
- Eine Wirking des Progesterone auf die Atmung.Arch. ges. physiol. 1948; 250: 42
- Ueber rhythmische Schwankungen von Atmung und Korpertemperatur im Menstruationzyklus.Arch. ges. physiol. 1948; 250: 694
- Further investigations about respiration in the cycle of the woman.Pflügers Arch. ges. Physiol. 1950; 252: 351
- Weitere Untersuchungen ueber der Wirkung der Sexhormone auf die Atmung.Arch. ges. physiol. 1950; 252: 216
- Respiratory and electrolyte effects induced by estrogen and progesterone.Fertil. & Steril. 1953; 4: 300
- The sensitivity of the respiratory center in pregnancy and after the administration of progesterone.Tr. A. Am. Physicians. 1959; 72: 173
- The effect of progesterone on the respiration of patients with emphysema and hypercarbia.J. Clin. Invest. 1960; 39: 34
- The respiratory effects of progesterone in severe pulmonary emphysema.Am. J. Med. 1959; 27: 551
- Measurement of oxygen tension in unstirred blood with a platinum electrode.J. Appl. Physiol. 1960; 15: 706
- Electrodes for blood pO2 and pCO2 determination.J. Appl. Physiol. 1958; 13: 515
- Analyzer for acute estimation of respiratory gases in one-half cubic centimeter samples.J. Biol. Chem. 1947; 167: 235
- Mechanical properties of the lung.Physiol. Rev. 1961; 41: 281
- Pulmonary insufficiency. I. Methods of analysis physiological classification. Standard values in normal subjects.Medicine. 1948; 27: 243
- Clinical spirometry in normal men.Am. J. Med. 1961; 30: 243
- Clinical and physiological aspects of a case of obesity, polycythemia and alveolar hypoventilation.J. Clin. Invest. 1955; 34: 1537
- A cardiopulmonary syndrome associated with extreme obesity.J. Clin. Invest. 1955; 34: 916
- Extreme obesity associated with alveolar hypoventilation.Am. J. Med. 1956; 21: 811
- A peculiar type of cardipulmonary failure associated with obesity.Am. J. Med. 1956; 21: 819
- Reversible cardiopulmonary syndrome with extreme obesity.Circulation. 1957; 16: 179
- Cardiopulmonary dysfunction and polycythemia in patients with extreme obesity.in: 5th ed. Proc. Staff Meet. Mayo Clinic. 32. 1957: 585
- The syndrome of alveolar hypoventilation.Am. J. Med. 1957; 23: 337
- Syndrome of extreme obesity and hypoventilation: studies of etiology.Ann. Int. Med. 1959; 51: 541
- Hypoventilation in obesity.J. Clin. Invest. 1959; 38: 500
- Regional distribution of ventilation and perfusion in obesity.J. Clin. Invest. 1967; 46: 475
- Pulmonary function in obesity.in: Presented at the Eastern Section-American Thoracic Society. October 7, 1966 (Saranac, New York)
Lyons, H. A. and Huang, C. T. Unpublished laboratory observations.
- Respiratory Function in Disease.W. B. Saunders Co, Philadelphia1964
- Effect of deep and quiet breathing on pulmonary compliance in man.J. Clin. Invest. 1960; 39: 143
- The effect of chest strapping on pulmonary function in normal subjects.in: 5th ed. Fed. Proc.18. 1959: 102
- Some effects of restriction of chest cage expansion on pulmonary function in man.J. Clin. Invest. 1960; 39: 573
- A comparison of the effect of voluntary hyperventilation in normal persons, patients with pulmonary emphysema and patients with cardiac disease.J. Lab. & Clin. Med. 1950; 36: 119
- Abnormalities of pulmonary gas exchange in obesity.Ann. Int. Med. 1960; 53: 1121
- The metabolic effect of progesterone in man.J. Clin. Endocrinol. 1955; 15: 1194
- Ventilatory effects of progesterone in acute metabolic acidosis and alkalosis with reference to the changes of cerebrospinal fluid.The Physiologist. 1966; 9: 207
- Drugs and respiration.Ann. Rev. Pharmacol. 1966; 6: 327
Received: June 12, 1967
☆This study was supported by the U.S. Public Health Service Grant No. 5T1 HE 5485-05 and NB 01594.
© 1968 Published by Elsevier Inc.