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Selective IgA deficiency with steatorrhea

A new syndrome
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      Abstract

      A patient suffering from a malabsorption syndrome resembling nontropical sprue was found to lack IgA in the serum and in several exocrine secretions. Immunohistochemical studies performed on intestinal biopsy specimens from this patient showed a marked deficiency of this tissue in plasma cells containing IgA.
      The relationship between the immunologic abnormality and the Steatorrhea is discussed, stressing the probability that the deficiency in IgA was the primary event.
      This patient was shown to have a gluten-induced enteropathy, and the suggestion is offered that patients with this disease may be suffering from some still unrecognized abnormality of the immune system.
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