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Primary defective iron reutilization

Response to testosterone therapy
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      Abstract

      Ferrokinetic data in five patients with primary defective iron reutilization before and following testosterone therapy are presented. The anemia in these patients is characterized by hypoferremia, increased iron stores and poor response to iron therapy. Iron utilization as measured by the intravenous injection of Fe59 citrate is normal, whereas iron reutilization as measured by the intravenous injection of Fe55-tagged hemoglobin solution is poor. Iron absorption also is poor. Testosterone therapy increased the total hemoglobin mass and total red cell mass in all patients and improved the reutilization of iron, but not the intestinal absorption of the metal.
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