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Abstract
A case of salt-wasting renal disease is presented, the outstanding features being
advanced renal insufficiency, polyuria, normal blood pressure and Addisonian-like
skin pigmentation. Sodium intakes varying between 250 and 300 mEq. per day were required
to maintain sodium balance and to stabilize renal function. A much greater tendency
to “waste” sodium chloride than sodium bicarbonate was demonstrated, the urinary sodium
loss being composed almost exclusively of sodium chloride. Studies of aldosterone
secretory rate during periods of low and high sodium intake revealed a persistently
increased aldosterone secretion rate, with a striking rise in response to relatively
mild salt restriction. The results of balance studies appear to be best explained
by postulating glomerulotubular imbalance with associated difficulty in the reabsorption
of sodium chloride and severe secondary hyperaldosteronism.
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References
- Salt-wasting renal disease.Quart. J. Med. 1959; 28: 425
- Characteristics of sodium wastage in severe chronic renal insufficiency.Clin. Res. 1964; 12: 69
- A controlled study of chlorothiazide as a diuretic agent.J. Chron. Dis. 1959; 10: 47
- Nitrogen determination by a continuous digestion and analysis system.Ann. New York Acad. Sc. 1960; 87: 792
- The colorimetric determination of phosphorus.J. Biol. Chem. 1925; 66: 375
- Determination of free magnesium ions in body fluids. Improved methods for free calcium ions, total calcium and total magnesium.Anal. Chem. 1960; 32: 711
- The in vivo stability of the tritium label in 1,2-H3-D-Aldosterone when used for measurement of aldosterone secretory rate by the double isotope dilution technique.Steroids. 1963; 3: 95
- Effect of various preparations of human growth hormone on aldosterone secretion rate of hypopituitary dwarfs.Am. J. Med. 1965; 38: 517
- Double isotope derivative assay of aldosterone in biological extracts.J. Biol. Chem. 1960; 235: 1639
- Renal failure simulating adrenocortical insufficiency.New England J. Med. 1944; 231: 76
- Saltlosing nephritis with fixed urinary composition.Am. J. Med. 1947; 22: 158
- Salt losing nephritis simulating adrenocortical insufficiency.New England J. Med. 1949; 240: 210
- Urinary flow and excretion of solutes during osmotic diuresis in hydropenic man.Am. J. Physiol. 1949; 156: 433
- Effect of potassium deficiency on the reabsorption of bicarbonate in the proximal tubule of the rat kidney.J. Clin. Invest. 1964; 43: 1976
- The functional adaptation of the diseased kidney. I. Glomerular filtration rate.J. Clin. Invest. 1964; 43: 1915
- Condition of the kidneys in salt losing nephritis.Lancet. 1952; 2: 458
- Aldosterone metabolism in renal insufficiency.in: Pasquelini J.R. Jayle M.F. Structure and Metabolism of Corticosteroids. Academic Press, New York1964: 142-156
- Calcium clearance as a function of sodium clearance in the dog.Am. J. Physiol. 1961; 200: 1099
- Salt-losing nephritis.Lancet. 1952; 2: 454
Article Info
Publication History
Received:
March 1,
1965
Footnotes
☆This study was supported by Grants H-03303, FR-35, T1-Am-5219 and AM-00180 from the National Institutes of Health.
Identification
Copyright
© 1965 Published by Elsevier Inc.
